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Nuclear deadenylation/polyadenylation factors regulate 3′ processing in response to DNA damage
We previously showed that mRNA 3′ end cleavage reaction in cell extracts is strongly but transiently inhibited under DNA‐damaging conditions. The cleavage stimulation factor‐50 (CstF‐50) has a roleExpand
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Positive and negative feedback loops in the p53 and mRNA 3′ processing pathways
Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA levelExpand
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PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells
mRNA deadenylation is under the control of cis-acting regulatory elements, which include AU-rich elements (AREs) and microRNA (miRNA) targeting sites, within the 3′ untranslated region (3′ UTRs) ofExpand
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Novel Small Interfering RNA–Containing Solution Protecting Donor Organs in Heart Transplantation
Background— Ischemia/reperfusion injury is a major factor in graft quality and subsequent function in the transplantation setting. We hypothesize that the process of RNA interference may be used toExpand
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To polyadenylate or to deadenylate
mRNA polyadenylation and deadenylation are important processes that allow rapid regulation of gene expression in response to different cellular conditions. Almost all eukaryotic mRNA precursorsExpand
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MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation
Background: Heart failure leads to mitochondrial dysfunction and metabolic abnormalities of the failing myocardium coupled with an energy-depleted state and cardiac remodeling. The mitochondrialExpand
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Serum exosomal protein profiling for the non-invasive detection of cardiac allograft rejection.
BACKGROUND Exosomes are cell-derived circulating vesicles that play an important role in cell-cell communication. Exosomes are actively assembled and carry messenger RNAs, microRNAs and proteins. TheExpand
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Increased de novo ceramide synthesis and accumulation in failing myocardium.
Abnormal lipid metabolism may contribute to myocardial injury and remodeling. To determine whether accumulation of very long-chain ceramides occurs in human failing myocardium, we analyzed myocardialExpand
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Preservation of Acyl Coenzyme A Attenuates Pathological and Metabolic Cardiac Remodeling Through Selective Lipid Trafficking.
BACKGROUND Metabolic remodeling in heart failure contributes to dysfunctional lipid trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty acid (LCFA) uptakeExpand
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Nucleolin phosphorylation regulates PARN deadenylase activity during cellular stress response
ABSTRACT Nucleolin (NCL) is an abundant stress-responsive, RNA-binding phosphoprotein that controls gene expression by regulating either mRNA stability and/or translation. NCL binds to the AU-richExpand
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