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The expression and significance of HIF-1α and GLUT-3 in glioma
Cyclooxygenase inhibitors suppress the expression of P2X3 receptors in the DRG and attenuate hyperalgesia following chronic constriction injury in rats
TLDR
Results demonstrate that up-regulated COX/PGE2 after nerve damage may play an important role in neuropathic pain and are highly involved in the expression of P2X(3) receptors in the DRG in CCI rats.
Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.
TLDR
Evidence is provided that the fecal microbiota from patients with CRC can promote tumorigenesis in germ-free mice and mice given a carcinogen, and up-regulation of genes involved in cell proliferation, stemness, apoptosis, angiogenesis, invasiveness, and metastasis are revealed in mice fed with stool from Patients with CRC.
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer.
TLDR
It is demonstrated that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in cancer and a potential target for effective tumor immunotherapy.
A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes
TLDR
In metformin-treated type 2 diabetes, a protein preload has the capacity to enhance the efficacy of vildagliptin to slow gastric emptying, increase plasma intact incretins, and reduce postprandial glycemia.
Isoform-specific expression of 14-3-3 proteins in human astrocytoma
CD8+ Cells Regulate the T helper-17 Response in an Experimental Murine Model of Sjögren Syndrome
TLDR
CD8+ regulatory cells suppress generation of a pathogenic Th17 response that has a pivotal role in DS-induced disruption of corneal barrier function in a murine desiccating stress model that resembles Sjögren syndrome.
IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way
TLDR
It is revealed that IMP3 is overdressed in prostate cancer, which accelerates the progression of prostate cancer through activating PI3K/AKT/mTOR signaling pathway via increasing SMURF1-mediated PTEN ubiquitination.
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