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The expression and significance of HIF-1α and GLUT-3 in glioma
Cyclooxygenase inhibitors suppress the expression of P2X3 receptors in the DRG and attenuate hyperalgesia following chronic constriction injury in rats
- Ying Wang, X. Zhang, Qu-lian Guo, W. Zou, Changsheng Huang, Jian-qin Yan
- MedicineNeuroscience Letters
- 5 July 2010
Results demonstrate that up-regulated COX/PGE2 after nerve damage may play an important role in neuropathic pain and are highly involved in the expression of P2X(3) receptors in the DRG in CCI rats.
Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.
Evidence is provided that the fecal microbiota from patients with CRC can promote tumorigenesis in germ-free mice and mice given a carcinogen, and up-regulation of genes involved in cell proliferation, stemness, apoptosis, angiogenesis, invasiveness, and metastasis are revealed in mice fed with stool from Patients with CRC.
Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer.
- Min Liu, Zan Tong, +17 authors Jun Yan
- Medicine, BiologyThe Journal of clinical investigation
- 16 January 2020
It is demonstrated that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in cancer and a potential target for effective tumor immunotherapy.
A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes
In metformin-treated type 2 diabetes, a protein preload has the capacity to enhance the efficacy of vildagliptin to slow gastric emptying, increase plasma intact incretins, and reduce postprandial glycemia.
Isoform-specific expression of 14-3-3 proteins in human astrocytoma
CD8+ Cells Regulate the T helper-17 Response in an Experimental Murine Model of Sjögren Syndrome
- X. Zhang, C. Schaumburg, +8 authors C. D. de Paiva
- Medicine, BiologyMucosal Immunology
- 11 September 2013
CD8+ regulatory cells suppress generation of a pathogenic Th17 response that has a pivotal role in DS-induced disruption of corneal barrier function in a murine desiccating stress model that resembles Sjögren syndrome.
IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way
- X. Zhang, Da-wei Wang, +5 authors Y. Shao
- Chemistry, MedicineJournal of experimental & clinical cancer…
- 16 September 2020
It is revealed that IMP3 is overdressed in prostate cancer, which accelerates the progression of prostate cancer through activating PI3K/AKT/mTOR signaling pathway via increasing SMURF1-mediated PTEN ubiquitination.