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In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19
TLDR
A retrospective study on 13,981 patients with COVID-19 in Hubei Province, China found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with a hazard ratio 0.58, implying the potential benefits of statin therapy in hospitalized subjects with CO VID-19. Expand
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
TLDR
It is revealed that methyltransferase-like 3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATAD2, suggesting a potential therapeutic target for osteosARcoma treatment. Expand
SM16, an Orally Active TGF-&bgr; Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model
TLDR
The results are the first to demonstrate the efficacy of an orally active, small-molecule ALK5/ALK4 inhibitor in a vascular fibrosis model and suggest the potential therapeutic application of these inhibitors inascular fibrosis. Expand
Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage
TLDR
GSDMD-induced pyroptosis mediated by the AIM2 inflammasome may be involved in early brain injury (EBI) after subarachnoid haemorrhage (SAH), and apoptosis was significantly suppressed via impeding the activation of caspase-3. Expand
High COX‐2 expression in cancer‐associated fibiroblasts contributes to poor survival and promotes migration and invasiveness in nasopharyngeal carcinoma
TLDR
The findings suggested that high expression of COX‐2 in CAF may serve as a new prognostic indicator for NPC metastasis and provide the possibility of targeting CAF for treating advanced NPC. Expand
Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis.
TLDR
These findings demonstrate a previously unappreciated therapeutic effect and signaling mechanism of low-dose sorafenib treatment in NASH and envision that this new therapeutic strategy for NASH has the potential to translate into a beneficial anti-NASH therapy with fewer adverse events than is observed in the drug's current use in HCC. Expand
FoxM1 Induced Paclitaxel Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter
TLDR
Targeting FoxM1 and its downstream effector PHB1 increased the sensitivity of pancreatic cells to pac litaxel treatment, providing potential therapeutic strategies for patients with paclitaxel resistance. Expand
Surface-layer protein from Lactobacillus acidophilus NCFM attenuates tumor necrosis factor-α-induced intestinal barrier dysfunction and inflammation.
TLDR
The ability of Slp to attenuate dysfunction of the intestinal epithelial barrier stimulated by TNF-α and to exert anti-inflammatory effects supports its potential use in the development of functional foods and in the prevention of inflammatory bowel diseases. Expand
A multifunctional anti-inflammatory drug that can specifically target activated macrophages, massively deplete intracellular H2O2, and produce large amounts CO for a highly efficient treatment of
TLDR
In vivo experiments confirmed that CPHs can massively deplete ROS in OA joints and effectively suppress the degradation of articular cartilage and their extracellular matrix and the high levels of CO generated in the joints do not result in notable changes in the HbCO levels in blood. Expand
Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance
TLDR
The role of Drp1 in the oncogenesis and prognosis of EBV-LMP1-positive nasopharyngeal carcinoma (NPC) was determined and a new function in remodeling mitochondrial morphology by activatingDrp1 is exhibited, providing novel insight into the role of EBv-L MP1-driven mitochondrial fission in regulating Drp 1 phosphorylation at serine 616 and serine637. Expand
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