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NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
BackgroundThe phosphatase PTEN governs the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway which is arguably the most important pro-survival pathway in neurons. Recently, PTEN has also beenExpand
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Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma
Osthole is a natural coumarin isolated from Umbelliferae plant monomers. Previous research has indicated that osthole exerts a wide variety of biological effects, acting as anti-seizure,Expand
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Elevated circulating PAI-1 levels are related to lung function decline, systemic inflammation, and small airway obstruction in chronic obstructive pulmonary disease
Background Plasminogen activator inhibitor-1 (PAI-1) and soluble urokinase-type plasminogen activator receptor (suPAR) participate in inflammation and tissue remolding in various diseases, but theirExpand
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Predicting Essential Genes and Proteins Based on Machine Learning and Network Topological Features: A Comprehensive Review
Essential proteins/genes are indispensable to the survival or reproduction of an organism, and the deletion of such essential proteins will result in lethality or infertility. The identification ofExpand
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Robotics in Lower-Limb Rehabilitation after Stroke
With the increase in the elderly, stroke has become a common disease, often leading to motor dysfunction and even permanent disability. Lower-limb rehabilitation robots can help patients to carry outExpand
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Hand Rehabilitation Robotics on Poststroke Motor Recovery
TLDR
The recovery of hand function is one of the most challenging topics in stroke rehabilitation. Expand
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Gender difference in plasma fatty-acid-binding protein 4 levels in patients with chronic obstructive pulmonary disease
Plasma FABP4 levels were higher in females with COPD compared with both males with COPD and healthy females. FABP4 levels correlated inversely with lung function, and positively with adiponectin andExpand
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Nasal DNA methylation is associated with childhood asthma.
AIM We aim to study DNA methylation (DNAm) variations associated with childhood asthma. METHODS Nasal DNAm was compared between sibling pairs discordant for asthma, 29 sib pairs for genome-wideExpand
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Calorimetric study of carbon nanotubes and aluminum
Abstract Differential scanning calorimeter (DSC) was used to investigate apparent activation energy and reaction order of the reaction of carbon nanotubes and aluminum by Kissinger equation and CraneExpand
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Clinical and genetic characteristics of Chinese patients with familial or sporadic pediatric cataract
BackgroundPediatric cataract is a clinically and genetically heterogeneous disease which is a significant cause of lifelong visual impairment and treatable blindness. Our study aims to investigateExpand
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