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A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)
In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named “2019 novel coronavirus (2019-nCoV)” by the World Health Organization (WHO) on 12 January 2020.… Expand
Talin depletion reveals independence of initial cell spreading from integrin activation and traction
- X. Zhang, Guoying Jiang, Yunfei Cai, S. Monkley, D. Critchley, M. Sheetz
- Medicine, Biology
- Nature Cell Biology
- 1 September 2008
Cell spreading, adhesion and remodelling of the extracellular matrix (ECM) involve bi-directional signalling and physical linkages between the ECM, integrins and the cell cytoskeleton. The… Expand
Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation*
The incidence of Alzheimer disease (AD) and vascular dementia is greatly increased following cerebral ischemia and stroke in which hypoxic conditions occur in affected brain areas. β-Amyloid peptide… Expand
Dishevelled promotes axon differentiation by regulating atypical protein kinase C
The atypical protein kinase C (aPKC) in complex with PAR3 and PAR6 is required for axon-dendrite differentiation, but the upstream factors responsible for regulating its activity are largely unknown.… Expand
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.
The incidence of Alzheimer disease (AD) and vascular dementia is greatly increased following cerebral ischemia and stroke in which hypoxic conditions occur in affected brain areas. beta-Amyloid… Expand
Quantifying the benefits of additional channels of multifocal VEP recording
For some individuals and for some locations, multifocal visual evoked potentials (mfVEP) may be too small or appear `too noisy' to be reliably measured. By adding electrodes, especially electrodes… Expand
Induction of hepatic enzymes and oxidative stress in Chinese rare minnow (Gobiocypris rarus) exposed to waterborne hexabromocyclododecane (HBCDD).
The objective of this study was to evaluate the sub-lethal toxicity of hexabromocyclododecane (HBCDD) in fish. Adult Chinese rare minnows as in vivo models were exposed to waterborne HBCDD from 1 to… Expand
Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin
The focal adhesion protein talin undergoes cycles of stretching and relaxation in living cells, suggesting a role in the transduction of mechanical into biochemical signals.
Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.
The Mre11/Rad50/NBS1 (MRN) complex is thought to be a critical sensor that detects damaged DNA and recruits ATM to DNA foci for activation. However, it remains to be established how the MRN complex… Expand
An interocular comparison of the multifocal VEP: a possible technique for detecting local damage to the optic nerve.
- D. Hood, X. Zhang, +4 authors R. Ritch
- Medicine, Biology
- Investigative ophthalmology & visual science
- 1 May 2000
PURPOSE To develop a quantitative measure of local damage to the ganglion cells/optic nerve based on an interocular comparison of multifocal visual evoked potentials (mVEP). METHODS Multifocal VEPs… Expand