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Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.
Individuals with neurofibromatosis type 1 (NF1) have a high incidence of osteoporosis and osteopenia. However, understanding of the cellular and molecular basis of these sequelae is incomplete.Expand
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MicroRNA-204 critically regulates carcinogenesis in malignant peripheral nerve sheath tumors.
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft tissue sarcomas accounting for 3%-10% of all soft tissue sarcomas. Neurofibromatosis type 1 (NF1) is the most importantExpand
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MicroRNA‐10b regulates tumorigenesis in neurofibromatosis type 1
MicroRNAs (miRNAs) are frequently deregulated in human tumors, and play important roles in tumor development and progression. The pathological roles of miRNAs in neurofibromatosis type 1 (NF1)Expand
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MicroRNAs in Osteoclastogenesis and Function: Potential Therapeutic Targets for Osteoporosis
  • Xiao Ji, X. Chen, X. Yu
  • Biology, Medicine
  • International journal of molecular sciences
  • 1 March 2016
Abnormal osteoclast formation and resorption play a fundamental role in osteoporosis pathogenesis. Over the past two decades, much progress has been made to target osteoclasts. The existingExpand
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MicroRNA-17-92 cluster regulates pancreatic beta-cell proliferation and adaptation
MiR-17-92 cluster contributes to the regulation of mammalian development, aging and tumorigenesis. The functional roles of miR-17-92 in pancreatic beta-cells are largely unknown. In this study, weExpand
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The Unique Metabolic Characteristics of Bone Marrow Adipose Tissue
Bone marrow adipose tissue (MAT) is distinct from white adipose tissue (WAT) or brown adipose tissue (BAT) for its location, feature and function. As a largely ignored adipose depot, it is situatedExpand
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Skeletal abnormalities in neurofibromatosis type 1: Approaches to therapeutic options
The skeleton is frequently affected in individuals with neurofibromatosis type 1, and some of these bone manifestations can result in significant morbidity. The natural history and pathogenesis ofExpand
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MiR-335 Inhibits Small Cell Lung Cancer Bone Metastases via IGF-IR and RANKL Pathways
  • M. Gong, J. Ma, +5 authors X. Yu
  • Biology, Medicine
  • Molecular Cancer Research
  • 21 August 2013
Small cell lung cancer (SCLC) is a rapidly progressing, incurable cancer that frequently spreads to bone. New insights are needed to identify therapeutic targets to prevent or retard SCLC metastaticExpand
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Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review)
  • L. Tian, X. Yu
  • Biology, Medicine
  • Molecular medicine reports
  • 11 March 2015
The association between lipid and bone metabolism has become an increasing focus of interest in recent years, and accumulating evidence has shown that atherosclerosis (AS) and osteoporosis (OP), aExpand
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Bone Marrow Adipocyte: An Intimate Partner With Tumor Cells in Bone Metastasis
The high incidences of bone metastasis in patients with breast cancer, prostate cancer and lung cancer still remains a puzzling issue. The “seeds and soil” hypothesis suggested that bone marrowExpand
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