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Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression.
The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based upon the tumor size and location and the presence of lymph node metastases. Here we show that gene expression… Expand
Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, and Methylation
Background Lung adenocarcinoma (LAD) has extreme genetic variation among patients, which is currently not well understood, limiting progress in therapy development and research. LAD intrinsic… Expand
Low molecular weight inhibitors of Myc–Max interaction and function
c-Myc is helix–loop–helix–leucine zipper (HLH–ZIP) oncoprotein that is frequently deregulated in human cancers. In order to bind DNA, regulate target gene expression, and function in a biological… Expand
Lung Squamous Cell Carcinoma mRNA Expression Subtypes Are Reproducible, Clinically Important, and Correspond to Normal Cell Types
Purpose: Lung squamous cell carcinoma (SCC) is clinically and genetically heterogeneous, and current diagnostic practices do not adequately substratify this heterogeneity. A robust, biologically… Expand
A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development
Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding family of transcription factors. We present evidence that ATF3 has a dichotomous role in cancer… Expand
Oral Resveratrol Therapy Inhibits Cancer-Induced Skeletal Muscle and Cardiac Atrophy In Vivo
The mechanism by which cancer mediates muscle atrophy has been delineated in the past 3 decades and includes a prominent role of tumor-derived cytokines, such as IL-6, TNFα, and IL-1. These cytokines… Expand
Mutation of the MXI1 gene in prostate cancer
- L. Eagle, X. Yin, A. Brothman, B. Williams, N. Atkin, E. Prochownik
- Biology, Medicine
- Nature Genetics
- 1 March 1995
The Mxi1 protein negatively regulates Myc oncoprotein activity and thus potentially serves a tumour suppressor function. MXI1 maps to chromosome 10q24–q25, a region that is deleted in some cases of… Expand
miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin
Epithelial–mesenchymal transition (EMT) has an established role in promoting tumor progression and the acquisition of therapeutic resistance. Here, the EMT phenotype was detected in… Expand
Clinical evaluation of a new molecular method for detection of micrometastases in head and neck squamous cell carcinoma.
- C. Shores, X. Yin, W. Funkhouser, W. Yarbrough
- Archives of otolaryngology--head & neck surgery
- 1 August 2004
OBJECTIVE To better detect occult cervical metastases. DESIGN RNA from 153 cervical lymph nodes was analyzed for the presence of squamous cell carcinoma using quantitative cytokeratin (CK) 14… Expand
NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo.
- A. Wysong, M. Couch, +8 authors M. Willis
- Biology, Medicine
- The American journal of pathology
- 1 March 2011
Cancer cachexia is a severe wasting syndrome characterized by the progressive loss of lean body mass and systemic inflammation. It occurs in approximately 80% of patients with advanced malignancy and… Expand