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Solution structure of P22 transcriptional antitermination N peptide–box B RNA complex
We have determined the solution structure of a 15-mer boxB RNA hairpin complexed with a 20-mer basic peptide of the N protein involved in bacteriophage P22 transcriptional antitermination. Complex… Expand
Deep penetration of an α-helix into a widened RNA major groove in the HIV-1 rev peptide–RNA aptamer complex
A combined NMR-molecular dynamics approach has been applied to determine the solution structure of a HIV-117-mer rev peptide bound to its 35-mer high affinity RNA aptamer binding site. Complex… Expand
Molecular recognition in the bovine immunodeficiency virus Tat peptide-TAR RNA complex.
BACKGROUND In lentiviruses such as human immunodeficiency virus (HIV) and bovine immunodeficiency virus (BIV), the Tat (trans-activating) protein enhances transcription of the viral RNA by complexing… Expand
RNA architecture dictates the conformations of a bound peptide.
BACKGROUND The biological function of several viral and bacteriophage proteins, and their arginine-rich subdomains, involves RNA-mediated interactions. It has been shown recently that bound peptides… Expand
In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite
- D. Zhou, M. Zhang, +6 authors S. Grimm
- Biology, Medicine
- Xenobiotica; the fate of foreign compounds in…
- 14 February 2011
AZD0328 was pharmacologically characterized as a α7 neuronal nicotinic receptor agonist intended for treatment of Alzheimer′s disease. In vitro AZD0328 cross species metabolite profile and enzyme… Expand
Mechanism of γ-secretase cleavage activation: Is γ-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
Maturation of γ-secretase requires an endoproteolytic cleavage in presenilin-1 (PS1) within a peptide loop encoded by exon 9 of the corresponding gene. Deletion of the loop has been demonstrated to… Expand
Relationship between Cefquinome PK/PD Parameters and Emergence of Resistance of Staphylococcus aureus in Rabbit Tissue-Cage Infection Model
In order to explore the relationship between different antibiotic dosing regimens and selective enrichment of resistant strains, tissue-cage infection model was established in rabbits to study… Expand
The PK/PD Interactions of Doxycycline against Mycoplasma gallisepticum
Mycoplasma gallisepticum is one of the most important pathogens that cause chronic respiratory disease in chicken. This study investigated the antibacterial activity of doxycycline against M.… Expand
Sequence preference of 7,12-dimethylbenz[a]anthracene-syn-diol epoxide-DNA binding in the mouse H-ras gene detected by UvrABC nucleases.
We have found that 7,12-dimethylbenz[a]anthracene-syn-diol epoxide (syn-DMBADE)-modified DNA fragments are sensitive to UvrABC incision. The incisions occur mainly seven bases 5' and four bases 3' of… Expand
Sequence-dependent interactions of two forms of UvrC with DNA helix-stabilizing CC-1065-N3-adenine adducts.
- M. Nazimiec, C. Lee, Y. Tang, X. Ye, R. Case, M. Tang
- Chemistry, Medicine
- 18 September 2001
The uvrA, uvrB, and uvrC genes of Escherichia coli control the initial steps of nucleotide excision repair. The uvrC gene product is involved in at least one of the dual incisions produced by the… Expand