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Antimalarial and toxic effect of triple combination of pyronaridine, sulfadoxine and pyrimethamine.
TLDR
Preliminary experiments on the drug effect on sporogony showed that the drug combination at the dose used could not completely interrupt the sporozoite formation although many retarded oocysts were found. Expand
Experimental studies on combinations of pyronaridine/primaquine versus chloroquine/primaquine.
TLDR
In animal models such as Plasmodium yoelii sporozoite infection in mice and P. cynomolgi sporozoites infection in rhesus monkeys, the tissue schizontocidal action of PQ was not affected by PND, so clinical evaluation of PND/PQ in comparison with CQ/P Q in treating vivax malaria is suggested. Expand
[Delay in emergence of resistance to pyronaridine phosphate in Plasmodium berghei].
  • B. R. Shao, X. Ye
  • Biology, Medicine
  • Zhongguo yao li xue bao = Acta pharmacologica…
  • 1 September 1986
TLDR
A high-degree pyronaridine resistance developed rapidly when P. berghei ANKA was passaged under drug pressure of pyronsaridine at high doses, but under lower drug pressure, no high resistance developed in the parasites of passage 31-45. Expand
[Development of pyronaridine-resistance in Plasmodium berghei].
TLDR
It was evident that a pyronsaridine-resistant line of P. berghei was fully developed as the parasites could tolerate a higher dose of pyronaridine than the hosts, bearing approximately a 300-fold resistance to pyronridine when compared with the parent line. Expand
[Stability of drug resistance of a pyronaridine-resistant line of Plasmodium berghei].
TLDR
The parasites under drug pressure for a long period retained not only the high resistance to pyronaridine but also cross resistance to chloroquine. Expand
[Tissue schizontocidal action and acute toxicity of trifluoroacetyl primaquine].
  • X. Ye, B. R. Shao
  • Biology, Medicine
  • Zhongguo yao li xue bao = Acta pharmacologica…
  • 1 July 1990
TLDR
Because M-8506 is less toxic than primaquine in mice and more effective in radical treatment of simian malaria, further studies on trifluoroacetyl primaquines are worthy to be considered. Expand
[Residual blood schizontocidal activity of pyronaridine against rodent malaria].
Detection of 54-kDa protein overexpressed by chloroquine-resistant Plasmodium berghei ANKA strain in pyronaridine-resistant P berghei ANKA strain.
TLDR
Both PR and CR parasites overexpressed the same proteins, which were localized to be mainly scattered in cytoplasm of trophozoites, schizonts, and merozoites of erythrocytic stage of P berghei. Expand
Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria.
TLDR
Blood schizontocidal effect of antimalarials were compared by 4-day suppressive test with an extended observation period of 31 days and pyronaridine (PND) exhibited the best effect, followed by amodiaquine (ADQ), mefloquine (MFQ), and qinghaosu (QHS). Expand
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