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Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.
We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC) phenotype of human colorectal cancer (CRC) cells. We showed that, without direct cell-cell contact, ECsExpand
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Overexpression of Snail induces epithelial–mesenchymal transition and a cancer stem cell–like phenotype in human colorectal cancer cells
Epithelial–mesenchymal transition (EMT) is a critical process providing tumor cells with the ability to migrate and escape from the primary tumor and metastasize to distant sites. Recently, EMT wasExpand
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Cadherin-11 Promotes the Metastasis of Prostate Cancer Cells to Bone
Bone is the most common site of metastases from prostate cancer. The mechanism by which prostate cancer cells metastasize to bone is not fully understood, but interactions between prostate cancerExpand
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  • Open Access
A secreted isoform of ErbB3 promotes osteonectin expression in bone and enhances the invasiveness of prostate cancer cells.
The propensity for prostate cancer to metastasize to bone led us and others to propose that bidirectional interactions between prostate cancer cells and bone are critical for the preferentialExpand
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  • Open Access
Biology and clinical management of prostate cancer bone metastasis.
Prostate cancer is the most common cancer among men in the United States. Advanced prostate cancer has a particular propensity to metastasize to bone, where it produces predominantly osteoblasticExpand
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  • Open Access
Bone Microenvironment and Androgen Status Modulate Subcellular Localization of ErbB3 in Prostate Cancer Cells
ErbB-3, an ErbB receptor tyrosine kinase, has been implicated in the pathogenesis of several malignancies, including prostate cancer. We found that ErbB-3 expression was up-regulated in prostateExpand
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  • Open Access
Aberrant expression of katanin p60 in prostate cancer bone metastasis
Katanin p60 is a microtubule‐severing protein and is involved in microtubule cytoskeleton organization in both mitotic and non‐mitotic processes. Its role in cancer metastasis is unknown.
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Androgen depletion up‐regulates cadherin‐11 expression in prostate cancer
Men with castration‐resistant prostate cancer (PCa) frequently develop metastasis in bone. The reason for this association is unclear. We have previously shown that cadherin‐11 (also known asExpand
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Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells.
Epithelial-mesenchymal interactions are of critical importance during tissue morphogenesis and repair. Although the cellular and molecular aspects of many of these interactions are beginning to beExpand
Role of Katanin in Prostate Cancer Bone Metastasis
Abstract : We previously identified katanin p60 as a differentially expressed protein in the bone marrow samples from prostate cancer patients with clinical evidence of bone metastasis. In order toExpand