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Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture.
TLDR
A directed and highly efficient SMC differentiation system by treating the monolayer-cultivated human embryonic stem cells with all-trans retinoid acid (atRA) and finding that fully differentiated SMCs were stable in phenotype and capable of contraction. Expand
Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma
TLDR
The results suggest that the EMT process is associated with tumor progression and a poor outcome in patients with intrahepatic cholangiocarcinoma, and inhibition of EMT might offer novel promising molecular targets for the treatment of affected patients. Expand
The Associated Ion between the VDR Gene Polymorphisms and Susceptibility to Hepatocellular Carcinoma and the Clinicopathological Features in Subjects Infected with HBV
TLDR
The FokI C>T polymorphisms may be used as a molecular marker to predict the risk and to evaluate the disease severity of HCC in those infected with HBV in patients with chronic hepatitis B virus infection. Expand
Antisense oligonucleotides targeting midkine inhibit tumor growth in an in situ human hepatocellular carcinoma model
TLDR
It is demonstrated that MK-AS was an effective antitumor antisense oligonucleotide in vivo in mice; its antitumors effect is associated with the increase of pro-apoptotic proteins, such as p53, Bax, and caspase-3, and the decrease of the anti-ap optotic protein, Bcl-2. Expand
Augmented miR-10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma.
TLDR
Findings indicate that miR-10b was upregulated in GC and may have a key role in GC pathogenesis and development through the downregulation of its target gene KLF4. Expand
Enhanced therapeutic effects of combined chemotherapeutic drugs and midkine antisense oligonucleotides for hepatocellular carcinoma.
TLDR
MK-AS increases the chemosensitivity in HepG2 cells and in situ human HCC model, and the combination of MK-AS and ADM has a much better in vitro and in vivo synergism. Expand
Conformational determinants of the intracellular localization of midkine.
TLDR
It is reported that human MK exclusively localized to the nucleus and nucleolus in HepG2 cells by using GFP as a tracking molecule and the results provide the first documentation about the determinants required for MK nuclear and nucleolar localization. Expand
Efficacy of postoperative antiviral combined transcatheter arterial chemoembolization therapy in prevention of hepatitis B-related hepatocellular carcinoma recurrence.
TLDR
Investigation of the role of antiviral therapy and postoperative transcatheter arterial chemoembolization in the prevention and treatment of hepatitis B-related HCC recurrence found post-operative TACE prevents early recurrence while antiviral Therapy prevents late recurrence of HCC. Expand
Histone deacetylase inhibitor promotes differentiation of embryonic stem cells into neural cells in adherent monoculture.
TLDR
The method combined differentiation induction effect of HDAC inhibitors and selective culture system to derive neural cells from ES cells, and implied the involvement of epigenetic regulation in neural differentiation. Expand
[Expression of midkine and its relationship with HBV infection in hepatocellular carcinomas].
TLDR
HCC overexpresses MK at the mRNA and protein level and the overexpression of the MK protein might be correlated with the existence of HBV DNA in the nuclei of carcinoma tissue. Expand
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