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Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China
It is concluded that actinomycetes isolated from mangrove habitats are a potentially rich source for the discovery of anti-infection and anti-tumor compounds, and of agents for treating neurodegenerative diseases and diabetes. Expand
Euphane and tirucallane triterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus.
Four new euphane-type triterpenes were isolated from a 60% EtOH extract of Euphorbia kansui, together with alpha-euphol, and their structures were elucidated on the basis of extensive analysis of their 1D and 2D NMR spectral data. Expand
Three new cytotoxic cyclic acylpeptides from marine Bacillus sp.
Three new cytotoxic cyclopeptides belonging to iturin class have been isolated from marine bacterium Bacillus sp. These three compounds have the cytotoxic activities. Their structures were determinedExpand
Antineoplastic agents. III: Steroidal glycosides from Solanum nigrum.
The cytotoxic assay indicated that 2 is the main antineoplastic agent in S. nigrum, and the structures of 1-3 were elucidated on the basis of chemical evidence and spectral analysis, especially by 2D-NMR analysis. Expand
Effects of oolong tea on plasma antioxidative capacity in mice loaded with restraint stress assessed using the oxygen radical absorbance capacity (ORAC) assay.
Findings suggested that oolong tea has beneficial effects on health related to its antioxidative action, which is probably due to the antioxidative properties of the tea. Expand
Characterization and Online Detection of Surfactin Isomers Based on HPLC-MSn Analyses and Their Inhibitory Effects on the Overproduction of Nitric Oxide and the Release of TNF-α and IL-6 in
It was revealed that the surfactin isomers showed strong inhibitory properties on the overproduction of nitric oxide and the release of IL-6 on LPS-induced murine macrophage cell RAW264, which will be very helpful for the development of this novel kind of natural product as new anti-inflammatory agents. Expand
Naringin improves bone properties in ovariectomized mice and exerts oestrogen‐like activities in rat osteoblast‐like (UMR‐106) cells
The present study was designed to determine if naringin could exert oestrogen‐like protective actions in bone, and found it possible to stimulate bone formation in vitro and in vivo. Expand
Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor‐dependent osteoblastic functions in UMR 106 cells
The mechanism(s) by which icariin prevents bone loss after ovariectomy (OVX) in vivo and stimulates osteoblastic functions in vitro is delineated. Expand
Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica.
The findings of bioactivity of 1-6 support the antifungus, antimitosis and anti-HIV-1 uses for W. indica roots and show moderate activity against microtubule polymerization. Expand
Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.
No compounds in the NCI's anticancer drug screen database have cytotoxicity patterns (mean graphs) similar to those of protodioscin, indicating that a potential novel mechanism of anticancer action is involved. Expand