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Andrographolide Attenuates Inflammation by Inhibition of NF-κB Activation through Covalent Modification of Reduced Cysteine 62 of p501
TLDR
A unique pharmacological mechanism of Andro’s protective anti-inflammatory actions is revealed, which suppressed the activation of NF-κB in stimulated endothelial cells and abrogated the cytokine- and endotoxin-induced peritoneal deposition of neutrophils, attenuated septic shock, and prevented allergic lung inflammation in vivo. Expand
Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans
TLDR
Findings suggest that berberine undergoes similar biotransformation in rats and humans. Expand
Epidermal growth factor receptor is a preferred target for treating Amyloid-β–induced memory loss
TLDR
It is concluded that EGFR is a preferred target for treating Aβ-induced memory loss because two clinically available drugs and three synthetic compounds not only showed positive effects in behavioral tests but also antagonized the Aβ oligomers-induced activation of the epidermal growth factor receptor (EGFR). Expand
Two new sesquiterpenes and six norsesquiterpenes from the solid culture of the edible mushroom Flammulina velutipes
Abstract One new sesquiterpene with a novel carbon skeleton, flammulinol A (1), one new isolactarane sesquiterpene and six isolactarane-related norsesquiterpenes, flammulinolides A–G (2–8), as wellExpand
New sesquiterpenes and calebin derivatives from Curcuma longa.
TLDR
Five new compounds and a new natural product were isolated along with five known bisabolane sesquiterpenes from Curcuma longa, all of which were new compounds. Expand
Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts.
TLDR
Results suggested that flavonoids from E. koreanum Nakai may improve the development of osteoblasts by promoting the ALP activity; and icariin might be one of the active constituents facilitating the differentiation of osteoblast-like cells. Expand
Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
  • Guanghui Wang, Haifeng Chen, +7 authors X. Yao
  • Biology, Medicine
  • Cancer letters
  • 8 September 2006
TLDR
Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells and the mechanism of the induced cytotoxicity was attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up- Regulation of Bax and down- regulation of BCL2, suggesting that methyl protidioscin may be a novel anti-mitotic agent. Expand
Isolation and characterization of polybrominated diphenyl ethers as inhibitors of microtubule assembly from the marine sponge Phyllospongia dendyi collected at Palau.
Two new polybrominated diphenyl ethers (1 and 2) were isolated by bioassay-guided separations together with nine known compounds (3-11) from the marine sponge Phyllospongia dendyi collected fromExpand
A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
  • Guanghui Wang, X. Guo, +7 authors X. Yao
  • Biology, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1 March 2012
Among the seven natural resveratrol analogs separated and identified from Pholidota yunnanensis R(OLFE), we found phoyunbene B (PYB, trans-3,4'-dihydroxy-2',3',5-trimethoxystilbene) was moreExpand
Four New Cuparene‐Type Sesquiterpenes from Flammulina velutipes
Flamvelutpenoids A–D (1–4), four new cuparene-type sesquiterpenes, were isolated from the solid culture of Flammulina velutipes. Their structures were elucidated by NMR experiments. The absoluteExpand
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