Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans
- F. Qiu, Zhiyong Zhu, Ning Kang, Shu-juan Piao, Gengyao Qin, X. Yao
- Chemistry, BiologyDrug Metabolism And Disposition
- 1 November 2008
Findings suggest that berberine undergoes similar biotransformation in rats and humans.
Andrographolide Attenuates Inflammation by Inhibition of NF-κB Activation through Covalent Modification of Reduced Cysteine 62 of p501
- Yi-Feng Xia, Bu-Qing Ye, J. Geng
- Biology, MedicineJournal of Immunology
- 15 September 2004
A unique pharmacological mechanism of Andro’s protective anti-inflammatory actions is revealed, which suppressed the activation of NF-κB in stimulated endothelial cells and abrogated the cytokine- and endotoxin-induced peritoneal deposition of neutrophils, attenuated septic shock, and prevented allergic lung inflammation in vivo.
Epidermal growth factor receptor is a preferred target for treating Amyloid-β–induced memory loss
- Lei Wang, Hsueh-Cheng Chiang, Y. Zhong
- Biology, ChemistryProceedings of the National Academy of Sciences
- 27 September 2012
It is concluded that EGFR is a preferred target for treating Aβ-induced memory loss because two clinically available drugs and three synthetic compounds not only showed positive effects in behavioral tests but also antagonized the Aβ oligomers-induced activation of the epidermal growth factor receptor (EGFR).
Two new sesquiterpenes and six norsesquiterpenes from the solid culture of the edible mushroom Flammulina velutipes
- Ya-qi Wang, Li Bao, Hongwei Liu
- Chemistry
- 8 April 2012
Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp.
- B. Bao, Qishi Sun, Jee H Jung
- ChemistryJournal of Natural Products
- 2007
Seven new and known bisindole alkaloids of the topsentin and hamacanthin classes were isolated from the MeOH extract of a marine sponge Spongosorites sp.
New sesquiterpenes and calebin derivatives from Curcuma longa.
- Y. Zeng, F. Qiu, Kyoko Takahashi, JianMu Liang, G. Qu, X. Yao
- ChemistryChemical and pharmaceutical bulletin
- 1 June 2007
Five new compounds and a new natural product were isolated along with five known bisabolane sesquiterpenes from Curcuma longa, all of which were new compounds.
A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
- Guanghui Wang, Xiaoyu Guo, X. Yao
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 1 March 2012
A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2.
- Yanyan Bu, Tao Shi, Zhong-xian Lu
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 15 January 2011
Synthesis, biological function and evaluation of Shikonin in cancer therapy.
- Fangfang Wang, X. Yao, Youwei Zhang, Jinshan Tang
- Biology, ChemistryFitoterapia
- 1 April 2019
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