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Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis.
TLDR
Wild-type Vpr-associated events, including procaspase-8 and -3 cleavage, loss of mitochondrial transmembrane potential, and DNA fragmentation factor activation are attenuated by R77Q Vpr, which highlights the pathophysiologic role of Vpr in HIV-induced immune disease and suggest a novel mechanism of LTNP. Expand
Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris.
TLDR
Results suggest that the purified Extract of Prunella vulgaris antagonizes HIV-1 infection of susceptible cells by preventing viral attachment to the CD4 receptor. Expand
Intracellular Transport of Human Immunodeficiency Virus Type 1 Genomic RNA and Viral Production Are Dependent on Dynein Motor Function and Late Endosome Positioning*
TLDR
The results demonstrate that dynein motor function is important for regulating Gag and vRNA egress on endosomal membranes in the cytoplasm to directly impact on viral production. Expand
Human Immunodeficiency Virus Type 1 Vpr Is a Positive Regulator of  Viral Transcription and Infectivity in Primary Human Macrophages
TLDR
It is demonstrated that the molecular determinants involved in G2-arresting T cells are also involved in increasing viral transcription in macrophages, even though these cells are refractive to the diploid DNA status typical of G2 phase. Expand
Isolation of drug‐resistant variants of HIV‐1 from patients on long‐term zidovudine therapy
TLDR
Whether drug-resistant variants of HIV-1 could be isolated from the peripheral blood mononuclear cells of 20 individuals with HIV infection on long-term zidovudine (AZT) therapy was determined and virus with a zidvudine-resistant phenotype was successfully obtained in five out of 20 cases. Expand
Human immunodeficiency virus type 1 Vpr‐mediated G2 cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A
TLDR
Interestingly, it is found that Vpr association with B55‐containing PP2A targets the enzymatic complex to the nucleus and, importantly, enhances the recruitment and dephosphorylation of the cdc25 substrate. Expand
Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression.
TLDR
HIV-1 Vpr appears to enhance processes that are coupled to transcription such as polyadenylation and could ultimately prove to optimize HIV-1 replication and contribute to HIV- 1 pathogenesis. Expand
Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function
TLDR
It is concluded that, although Asn563 and Asn618 are not required for EBOV GP expression, they synergistically regulate its maturation, which determines its functionality. Expand
Analysis of HIV-1 Vpr determinants responsible for cell growth arrest in Saccharomyces cerevisiae
TLDR
Vpr-induced growth arrest in budding yeast can be effectively inhibited by GST-fused di-W peptide through a specific interaction of di-w peptide with Vpr functional domain, which includes α-helix I (17–33) and α- helix III (53–83). Expand
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