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Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase
Summary Nucleotide analog inhibitors, including broad-spectrum remdesivir and favipiravir, have shown promise in in vitro assays and some clinical studies for COVID-19 treatment, this despite anExpand
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The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs
Over the past decade, two independent technologies have emerged and been widely adopted by the neuroscience community for remotely controlling neuronal activity: optogenetics which utilize engineeredExpand
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Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug Carmofur
The antineoplastic drug Carmofur was shown to inhibit SARS-CoV-2 main protease (Mpro). Here the X-ray crystal structure of Mpro in complex with Carmofur reveals that the carbonyl reactive group ofExpand
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Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties
  • N. Urs, S. Gee, +11 authors M. Caron
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 1 December 2016
Significance Schizophrenia is a debilitating psychiatric disorder characterized by positive, negative, and cognitive symptoms. Current antipsychotic drugs, including D2 receptor (D2R) partial agonistExpand
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A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).
PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is essential for maturation of ribosomes, may have a role in lipogenesis, and is implicated in severalExpand
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A new car-following model accounting for varying road condition
In this paper, we develop a new car-following model with consideration of varying road condition based on the empirical data. Firstly, we explore the effects of road condition on uniform flow fromExpand
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Discovery of SIAIS178 as an effective BCR-ABL degrader by recruiting von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
The oncogenic fusion protein BCR-ABL is the driving force of leukemogenesis in chronic myeloid leukemia (CML). Despite great progress for CML treatment through application of tyrosine kinaseExpand
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Modeling Pedestrian Violation Behavior at Signalized Crosswalks in China: A Hazards-Based Duration Approach
Objective: Pedestrian violation is a major cause of traffic accidents involving pedestrians. The research objectives were to investigate the relationship between waiting duration and pedestrianExpand
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THE MARGINAL DECREASE OF LANE CAPACITY WITH THE NUMBER OF LANES ON HIGHWAY
This paper attempts to investigate the impact of the number of lanes on highway capacity. Methodologically, we provide a better understanding of the relationship between highway capacity and itsExpand
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Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK).
Anaplastic lymphoma kinase (ALK) activation has been associated with many types of human cancer. Significant efforts have been devoted to the development of ALK inhibitors to antagonize the kinaseExpand
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