• Publications
  • Influence
ADME evaluation in drug discovery
  • T. Hou, X. Xu
  • Chemistry, Medicine
  • Journal of molecular modeling
  • 1 December 2002
Abstract. In this study, the relationships between the brain–blood concentration ratio of 96 structurally diverse compounds with a large number of structurally derived descriptors were investigated.Expand
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Use of Natural Products as Chemical Library for Drug Discovery and Network Pharmacology
Background Natural products have been an important source of lead compounds for drug discovery. How to find and evaluate bioactive natural products is critical to the achievement of drug/leadExpand
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Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells
ABSTRACT Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novelExpand
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Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.
  • X. Xu, Zhongyi Fan, +17 authors Q. Ye
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1 February 2013
MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers; however, miRNA regulation of virus-related cancer development and progression remains poorly understood. Here, weExpand
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Antiviral compounds from traditional Chinese medicines Galla Chinese as inhibitors of HCV NS3 protease.
Under the guidance of bioassay, the EtOAc extract fraction of the Traditional Chinese Medicine (TCM) Galla Chinese was found to be efficient in inhibiting the NS3 protease of HCV and purified theExpand
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Protein interaction networks of Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster: Large‐scale organization and robustness
High‐throughput screens have begun to reveal protein interaction networks in several organisms. To understand the general properties of these protein interaction networks, a systematic analysis ofExpand
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MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3
MiR-125a has been characterized as a tumor suppressor in several cancers. However, the role of miR-125a in cervical cancer is unknown. In this study, we found the expression of miR-125a wasExpand
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A Chandra Survey of Milky Way Globular Clusters. I. Emissivity and Abundance of Weak X-Ray Sources
Based on archival {\it Chandra} data, we have carried out an X-ray survey of 69, or nearly half the known population of, Milky Way globular clusters (GCs), focusing on weak X-ray sources, mainlyExpand
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Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown.Expand
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