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Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
TLDR
SorLA acts as a sorting receptor that protects APP from processing into Abeta and thereby reduces the burden of amyloidogenic peptide formation and may increase Abeta production and plaque formation and promote spontaneous AD. Expand
Teams as innovative systems: multilevel motivational antecedents of innovation in R&D teams.
TLDR
Analyses of multisource data from 428 members of 95 research and development teams across 33 Chinese firms indicated that team-level support for innovation climate captured motivational mechanisms that mediated between transformational leadership and team innovative performance, whereas members' motivational states mediated between proactive personality and individual innovative performance. Expand
Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics
TLDR
The establishment of this new cell line has completed the stepwise metastatic HCC cell mode system, which was characterized by a similar genetic background but with significant differences in spontaneous metastasis behavior and supports the theory that cancer metastasis is a highly selective dynamic process. Expand
Penetration and distribution of PLGA nanoparticles in the human skin treated with microneedles.
TLDR
The results suggested that microneedles could enhance the intradermal delivery of PLGA nanoparticles and the biodegradable nanoparticles would sustain drug release in the skin and supply the skin with drug over a prolonged period. Expand
A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes
TLDR
Evidence is provided that small molecule LXR/RXR agonists can effectively mediate apoE synthesis and secretion as well as cholesterol homeostasis in astrocytes and treatment of mice with a specific synthetic LXR agonist resulted in up‐regulation of ApoE mRNA and protein in both hippocampus and cerebral cortex. Expand
Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes.
TLDR
It is concluded that insulin and beta-agonists act directly at the adipocytes in opposing fashions to regulate the production of adiponectin and leptin, and that a PI3K-PDE3B-cAMP pathway mediates the effects of insulin to restore beta-agonist/cAMP-suppressed secretion and expression of these two adipokines. Expand
Bacterial community composition of a shallow hypertrophic freshwater lake in China, revealed by 16S rRNA gene sequences.
TLDR
The phylogenetic composition of a bacterial community from a hypertrophic freshwater lake in China was investigated by sequencing cloned 16S rRNA genes, and it showed that the composition of bacterial community in the July library was the most diverse one. Expand
Integrin Receptor Activation Triggers Converging Regulation of Cav1.2 Calcium Channels by c-Src and Protein Kinase A Pathways*
TLDR
It is shown that currents through heterologously expressed neuronal and smooth muscle CaL channel isoforms are acutely potentiated following α5β1 integrin activation, and integrin-ECM interactions are a common mechanism for the acute regulation of CaL channels in brain and muscle. Expand
Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide
TLDR
It is demonstrated that glial apoE and apoJ expression are independently regulated by LPS in microglia and astroglia, respectively, and that activatedmicroglia are the predominant source of apo E in mixed glial cultures. Expand
Quercetin attenuates collagen‐induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1‐mediated anti‐inflammatory effect
TLDR
Takeaway is that QU attenuates CIA via modulating the Th17/Treg balance, inhibiting NLRP3 inflammasome activation as well as activating HO‐1‐mediated anti‐inflammatory response, which counteracted arthritis via restoration of the Th 17/T Reg balance. Expand
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