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p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity.
- X. Wu, H. Zhao, +5 authors M. Spitz
- Biology, Medicine
- Journal of the National Cancer Institute
- 1 May 2002
BACKGROUND The p53 tumor suppressor protein is important in cell-cycle control, apoptosis, and DNA repair. Mutations in p53 have been associated with inherited cancer susceptibility. Because there is… Expand
Telomere dysfunction: a potential cancer predisposition factor.
BACKGROUND Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between telomere length and cancer risk… Expand
The landscape of recombination in African Americans
Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a… Expand
XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity.
XPA, a DNA binding protein in the nucleotide excision repair (NER) pathway, modulates damage recognition. Recently, a common single-nucleotide polymorphism (A --> G) of unknown function was… Expand
A Meta-Analysis Identifies New Loci Associated with Body Mass index in Individuals of African Ancestry
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the… Expand
Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
The candidate-gene approach in association studies of polygenic diseases has often yielded conflicting results. In this hospital-based case-control study with 696 white patients newly diagnosed with… Expand
Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer.
- X. Wu, J. Gu, +11 authors J. Ajani
- Journal of clinical oncology : official journal…
- 10 August 2006
PURPOSE Understanding how specific genetic variants modify drug action pathways may provide informative blueprints for individualized chemotherapy. METHODS We applied a pathway-based approach to… Expand
Serum levels of insulin-like growth factor I and risk of squamous intraepithelial lesions of the cervix.
- X. Wu, G. Tortolero-Luna, H. Zhao, D. Phatak, M. Spitz, M. Follen
- Clinical cancer research : an official journal of…
- 15 August 2003
Squamous intraepithelial lesions (SILs) are areas of precancerous growth in the cervix that can be indicative of future cervical cancer. Insulin-like growth factors (IGFs) and their binding proteins… Expand
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
- N. Rothman, M. García-Closas, +107 authors S. Chanock
- Biology, Medicine
- Nature Genetics
- 17 September 2010
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five… Expand
Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer.
Cytochrome P4502E1 (CYP2E1) is involved in the metabolic activation of carcinogenic N-nitrosoamines. We therefore assessed the genotype frequencies of PstI or RsaI CYP2E1 restriction fragment length… Expand