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Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion
Subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion develops with progressive white matter and cognitive impairments, yet no effective therapy is available. We… Expand
Pinellia pedatisecta agglutinin interacts with the methylosome and induces cancer cell death
Pinellia pedatisecta agglutinin (PPA) is a specific mannose-binding plant lectin accumulated in the tuber of P. pedatisecta. In the work presented, the cytotoxicity of PPA to cancer cells was… Expand
5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.
- Alexander L. Ruchelman, S. Singh, +6 authors E. Lavoie
- Medicine, Chemistry
- Bioorganic & medicinal chemistry
- 1 May 2003
5H-Dibenzo[c,h]1,6-naphthyridine-6-ones can exhibit potent antitumor activity. The effect of varied substituents at the 5-position of 5H-8,9-dimethoxy-2,3-methylenedioxydibenzo[c,h]1,6-naphthyridine… Expand
Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery.
- Z. He, X. Zheng, +6 authors Y. Q. Wei
- Medicine, Chemistry
- International journal of pharmaceutics
- 15 September 2010
The glycyrrhetinic acid-modified stealth cationic liposomes (GA-PEG-CLs) loaded with pDNA (GA-PEG-CLPs) were developed and found to transfect human hepatocellular carcinoma cell line HepG2 with high… Expand
CD123 targeting oncolytic adenoviruses suppress acute myeloid leukemia cell proliferation in vitro and in vivo
We report here a novel strategy to redirect oncolytic adenoviruses to CD123 by carry a soluble coxsackie-adenovirus receptor (sCAR)-IL3 expression cassette in the viral genome to form Ad.IL3, which… Expand
Expression of galectin-3 in cervical cancer and its clinical significance
Objective: To evaluate the expression of galectin-3(Gal-3) in cervical cancer tissues and its correlation with clinicopathological and survival variables. Methods: One hundred and seventy-four… Expand
Allelopathic interactions between Potamogelon maackianus and Microcystis aeruginosa
The allelopathic interactions between Potamogeton maackianus and toxic cyanobacteria (Microcystis aeruginosa) were studied. P maackianus inhibited the growth of M. aeruginosa, both in a coexistence… Expand
A semi-analytic method for studying optical properties of aligned carbon nanotubes
A method is presented for calculating the bulk optical properties of aligned carbon nanotubes. The method is based on an improved equivalent dielectric function of carbon nanotubes and an analytical… Expand
A novel Janus-type AT nucleoside with benzoyl protecting groups forming a pleated-sheet structure.
- Mei Ying Pan, X. Wu, Dai Bing Luo, W. Huang, Y. He
- Chemistry, Medicine
- Acta crystallographica. Section C, Crystal…
- 15 May 2011
The title compound, 5-amino-8-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrimido[4,5-d]pyrimidine-2,4(3H,8H)-dione methanol monosolvate, C(32)H(25)N(5)O(9)·CH(4)O, which crystallized slowly from… Expand
Photo-crosslinked hierarchically honeycomb-patterned/macroporous scaffolds of calcium phosphate cement promote MC3T3-E1 cell functions
Advanced technology has enabled us to investigate cell functions in biomimetic honeycomb films or macroporous inorganic scaffolds to tentatively seek more powerful engineered biomaterials for bone… Expand