• Publications
  • Influence
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling.
  • X. Wu, T. Zhang, +7 authors D. Bers
  • Medicine, Biology
  • The Journal of clinical investigation
  • 1 March 2006
Previous work showed that calmodulin (CaM) and Ca2+-CaM-dependent protein kinase II (CaMKII) are somehow involved in cardiac hypertrophic signaling, that inositol 1,4,5-trisphosphate receptorsExpand
  • 413
  • 28
  • Open Access
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
  • J. Liu, S. Pan, +33 authors J. Harris
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 25 November 2013
Significance Targeting the Wnt pathway in cancer is an attractive therapeutic approach. However, success has been limited because of the lack of effective therapeutic agents and the lack ofExpand
  • 457
  • 24
  • Open Access
Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis
  • X. Xia, S. Qian, +6 authors H. Zheng
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 21 August 2001
Presenilin 1 (PS1) is required for the proteolytic processing of Notch and the β-amyloid precursor protein (APP), molecules that play pivotal roles in cell-fate determination during development andExpand
  • 219
  • 13
Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein.
Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress induces YAP cytoplasmicExpand
  • 153
  • 13
Sarcoplasmic Reticulum and Nuclear Envelope Are One Highly Interconnected Ca2+ Store Throughout Cardiac Myocyte
  • X. Wu, D. Bers
  • Chemistry, Medicine
  • Circulation research
  • 4 August 2006
Previous ventricular myocyte studies indicated that ryanodine receptors (RyRs) are in the sarcoplasmic reticulum (SR) and are critical in excitation–contraction coupling, whereas the inositolExpand
  • 160
  • 10
TRPC channels are necessary mediators of pathologic cardiac hypertrophy
Pathologic hypertrophy of the heart is regulated through membrane-bound receptors and intracellular signaling pathways that function, in part, by altering Ca2+ handling and Ca2+-dependent signalingExpand
  • 220
  • 9
Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells
Recently, it was demonstrated that lineage-committed oligodendrocyte precursor cells (OPCs) can be converted to multipotent neural stem-like cells, capable of generating both neurons and glia afterExpand
  • 115
  • 9
  • Open Access
Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria.
  • Y. Deng, X. Wu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 24 October 2000
Mitochondria is believed to play a central role in p53-mediated apoptosis. However, the signal transduction pathways leading to mitochondria remain unclear. Here, we report that translocation of BaxExpand
  • 184
  • 8
Ultrasmall near-infrared gold nanoclusters for tumor fluorescence imaging in vivo.
In this paper, we explore the possibility of using ultrasmall near-infrared (NIR) gold nanoclusters (AuNCs) as novel contrast imaging agents for tumor fluorescence imaging in vivo. The fluorescenceExpand
  • 261
  • 8
Isoflurane-Induced Caspase-3 Activation Is Dependent on Cytosolic Calcium and Can Be Attenuated by Memantine
Increasing evidence indicates that caspase activation and apoptosis are associated with a variety of neurodegenerative disorders, including Alzheimer's disease. We reported that anesthetic isofluraneExpand
  • 102
  • 7
  • Open Access