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Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study
BACKGROUND The health benefits of leisure-time physical activity are well known, but whether less exercise than the recommended 150 min a week can have life expectancy benefits is unclear. We… Expand
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
To identify risk variants for lung cancer, we conducted a multistage genome-wide association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smoking… Expand
Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers.
The survival of patients with oral squamous cell carcinoma (OSCC) has not changed significantly in several decades, leading clinicians and investigators to search for promising molecular targets. To… Expand
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not been well studied. We… Expand
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
We conducted a genome-wide association study on 969 bladder cancer cases and 957 controls from Texas. For fast-track validation, we evaluated 60 SNPs in three additional US populations and validated… Expand
Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer.
MicroRNAs (miRNA) are small noncoding RNA molecules involved in a diversity of cellular functions. Although it has been reported that global suppression of the miRNA biogenesis pathway leads to… Expand
Genetic Variations in MicroRNA-Related Genes Are Novel Susceptibility Loci for Esophageal Cancer Risk
MicroRNAs (miRNA) can act as oncogenes or tumor suppressors and modulate the expression of approximately one third of all human genes. To test the hypothesis that adverse alleles in miRNA-related… Expand
A risk model for prediction of lung cancer.
BACKGROUND Reliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool… Expand
Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival.
- D. Leibovici, H. Grossman, +6 authors X. Wu
- Journal of clinical oncology : official journal…
- 20 August 2005
PURPOSE Since chronic inflammation contributes to tumorigenesis, we hypothesized that the risk and clinical outcome of bladder cancer (BC) might be modulated by genetic variations in inflammation… Expand
Single Nucleotide Polymorphisms of microRNA Machinery Genes Modify the Risk of Renal Cell Carcinoma
Purpose: MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of basic cellular functions through posttranscriptional regulations on their target… Expand