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Curcumin Inhibits Neurotensin-Mediated Interleukin-8 Production and Migration of HCT116 Human Colon Cancer Cells
Purpose: Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers that possess high-affinity neurotensin receptors. Cytokine/chemokine… Expand
DNA methylation contributes to expression of the human neurotensin/neuromedin N gene.
- Z. Dong, X. Wang, Qingzheng Zhao, C. Townsend, B. Evers
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 1 March 1998
The gut and liver share a common embryological origin. The gene encoding the gut hormone neurotensin/neuromedin N (NT/N) is expressed in the adult small bowel, and NT/N is transiently expressed in… Expand
Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis.
- Fredrick J. Bohanon, X. Wang, +6 authors R. Radhakrishnan
- Biology, Medicine
- The Journal of surgical research
- 1 December 2015
BACKGROUND
Activated hepatic stellate cells (HSCs) are responsible for excess extracellular matrix (ECM) protein deposition in liver fibrosis. Previously, our group reported that the natural compound… Expand
STAT3 Inhibition Suppresses Hepatic Stellate Cell Fibrogenesis: HJC0123, a Potential Therapeutic Agent for Liver Fibrosis.
- O. Nunez Lopez, Fredrick J. Bohanon, +7 authors R. Radhakrishnan
- Chemistry, Medicine
- RSC advances
- 19 October 2016
Hepatic Stellate Cells (HSCs) are the major source of the excessive extracellular matrix (ECM) production that replaces liver parenchyma with fibrous tissue during liver fibrosis. The signal… Expand
Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis.
- Fredrick J. Bohanon, X. Wang, +5 authors R. Radhakrishnan
- Biology, Medicine
- The Journal of surgical research
- 1 July 2014
BACKGROUND
Liver fibrosis is a common response to liver injury and, in severe cases, leads to cirrhosis. The hepatic stellate cells (HSCs) become activated after liver injury and play a significant… Expand
Effects of 5-azacytidine and butyrate on differentiation and apoptosis of hepatic cancer cell lines.
OBJECTIVE
To determine the cellular effects of 5-azacytidine (5-azaC) and sodium butyrate on two human liver cancers, HepG2 and Hep3B.
SUMMARY BACKGROUND DATA
Primary liver cancer is a significant… Expand
Suppression of Neurotensin Receptor Type 1 Expression and Function by Histone Deacetylase Inhibitors in Human Colorectal Cancers
- X. Wang, Lindsey N. Jackson, S. M. Johnson, Q. Wang, B. Evers
- Biology, Medicine
- Molecular Cancer Therapeutics
- 27 July 2010
Neurotensin, a gut peptide, stimulates the growth of colorectal cancers that possess the high-affinity neurotensin receptor (NTR1). Sodium butyrate (NaBT) is a potent histone deacetylase inhibitor… Expand
Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo.
- H. Chen, Amy A. Mrazek, +7 authors J. Zhou
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 July 2014
Accumulating evidence suggests that activated pancreatic stellate cells (PSC) play an important role in chronic pancreatitis (CP), and inhibition of the activated PSC is considered as a potential… Expand
Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON
Mitochondria, organelles essential for ATP production, play a central role in a number of cellular functions, including the regulation of insulin secretion. Neurotensin (NT), an important regulator...
Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway
- C. Cummins, X. Wang, +4 authors R. Radhakrishnan
- Chemistry, Medicine
- International journal of molecular sciences
- 24 May 2018
Hepatic stellate cell (HSC) activation is responsible for hepatic fibrogenesis and is associated with an overexpression of transcription 3 (STAT3). Luteolin, a common dietary flavonoid with potent… Expand
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