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- Publications
- Influence
Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance
- X. Chen, X. Wang, B. Kaufman, R. Butow
- Biology, Medicine
- Science
- 4 February 2005
Mitochondrial DNA (mtDNA) is essential for cells to maintain respiratory competency and is inherited as a protein-DNA complex called the nucleoid. We have identified 22 mtDNA-associated proteins in… Expand
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
- C. Zhang, Meihua Lin, +5 authors Z. Feng
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 19 September 2011
Regulation of energy metabolism is a novel function of p53 in tumor suppression. Parkin (PARK2), a Parkinson disease-associated gene, is a potential tumor suppressor whose expression is frequently… Expand
In Vivo Priming of Cd4 T Cells That Produce Interleukin (Il)-2 but Not IL-4 or Interferon (Ifn)-γ, and Can Subsequently Differentiate into IL-4–Or IFN-γ–Secreting Cells
- X. Wang, T. Mosmann
- Biology, Medicine
- The Journal of experimental medicine
- 15 October 2001
The differentiation of antigen-stimulated naive CD4 T cells into T helper (Th)1 or Th2 effector cells can be prevented in vitro by transforming growth factor (TGF)-β and anti–interferon (IFN)-γ.… Expand
Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis
- T. Zheng, Jizhou Wang, +7 authors W. Hu
- Biology, Medicine
- Nature communications
- 20 December 2013
Tumor suppressor p53 is frequently mutated in tumors. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 often accumulates at… Expand
Mgm101 Is a Rad52-related Protein Required for Mitochondrial DNA Recombination*
- MacMillan Mbantenkhu, X. Wang, +5 authors X. Chen
- Biology, Medicine
- The Journal of Biological Chemistry
- 25 October 2011
Background: The mechanisms of homologous recombination and recombinational repair of double-stranded DNA breaks in mitochondria are poorly understood. Results: The yeast mitochondrial nucleoid… Expand
Dominant membrane uncoupling by mutant adenine nucleotide translocase in mitochondrial diseases.
- X. Wang, Kelly Salinas, X. Zuo, B. Kucejová, X. Chen
- Biology, Medicine
- Human molecular genetics
- 15 December 2008
Adenine nucleotide translocase (Ant) is the most abundant protein on the mitochondrial inner membrane (MIM) primarily involved in ADP/ATP exchange. Ant also possesses a discrete membrane uncoupling… Expand
Effect of bioaugmented inoculation on microbiota dynamics during solid-state fermentation of Daqu starter using autochthonous of Bacillus, Pediococcus, Wickerhamomyces and Saccharomycopsis.
- Pan Li, W. Lin, +4 authors Weitie Lin
- Biology, Medicine
- Food microbiology
- 1 February 2017
Daqu, a traditional fermentation starter that is used for Chinese liquor and vinegar production, is still manufactured through a traditional spontaneous solid-state fermentation process with no… Expand
Reduced cytosolic protein synthesis suppresses mitochondrial degeneration
- X. Wang, X. Zuo, B. Kucejová, X. Chen
- Biology, Medicine
- Nature Cell Biology
- 1 September 2008
Mitochondrial function degenerates with ageing and in ageing-related neuromuscular degenerative diseases, causing physiological decline of the cell. Factors that can delay the degenerative process… Expand
Psc-AFP, an antifungal protein with trypsin inhibitor activity from Psoralea corylifolia seeds
An antifungal protein designated as Psc-AFP, with an apparent molecular mass of 18kDa, was isolated from a traditional Chinese herb, malaytea scurfpea (Psoralea corylifolia L.). The isolation… Expand
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