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Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance
Mitochondrial DNA (mtDNA) is essential for cells to maintain respiratory competency and is inherited as a protein-DNA complex called the nucleoid. We have identified 22 mtDNA-associated proteins inExpand
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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
Regulation of energy metabolism is a novel function of p53 in tumor suppression. Parkin (PARK2), a Parkinson disease-associated gene, is a potential tumor suppressor whose expression is frequentlyExpand
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In Vivo Priming of Cd4 T Cells That Produce Interleukin (Il)-2 but Not IL-4 or Interferon (Ifn)-γ, and Can Subsequently Differentiate into IL-4–Or IFN-γ–Secreting Cells
  • X. Wang, T. Mosmann
  • Biology, Medicine
  • The Journal of experimental medicine
  • 15 October 2001
The differentiation of antigen-stimulated naive CD4 T cells into T helper (Th)1 or Th2 effector cells can be prevented in vitro by transforming growth factor (TGF)-β and anti–interferon (IFN)-γ.Expand
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Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis
Tumor suppressor p53 is frequently mutated in tumors. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 often accumulates atExpand
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Mgm101 Is a Rad52-related Protein Required for Mitochondrial DNA Recombination*
Background: The mechanisms of homologous recombination and recombinational repair of double-stranded DNA breaks in mitochondria are poorly understood. Results: The yeast mitochondrial nucleoidExpand
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Dominant membrane uncoupling by mutant adenine nucleotide translocase in mitochondrial diseases.
Adenine nucleotide translocase (Ant) is the most abundant protein on the mitochondrial inner membrane (MIM) primarily involved in ADP/ATP exchange. Ant also possesses a discrete membrane uncouplingExpand
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Effect of bioaugmented inoculation on microbiota dynamics during solid-state fermentation of Daqu starter using autochthonous of Bacillus, Pediococcus, Wickerhamomyces and Saccharomycopsis.
Daqu, a traditional fermentation starter that is used for Chinese liquor and vinegar production, is still manufactured through a traditional spontaneous solid-state fermentation process with noExpand
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CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies.
  • X. Wang, W. Wang, +12 authors R. Li
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 1 March 2014
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Reduced cytosolic protein synthesis suppresses mitochondrial degeneration
Mitochondrial function degenerates with ageing and in ageing-related neuromuscular degenerative diseases, causing physiological decline of the cell. Factors that can delay the degenerative processExpand
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Psc-AFP, an antifungal protein with trypsin inhibitor activity from Psoralea corylifolia seeds
An antifungal protein designated as Psc-AFP, with an apparent molecular mass of 18kDa, was isolated from a traditional Chinese herb, malaytea scurfpea (Psoralea corylifolia L.). The isolationExpand
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