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Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex
Large-scale surveys of single-cell gene expression have the potential to reveal rare cell populations and lineage relationships but require efficient methods for cell capture and mRNA sequencing.… Expand
Single cell RNA Seq reveals dynamic paracrine control of cellular variation
High-throughput single-cell transcriptomics offers an unbiased approach for understanding the extent, basis and function of gene expression variation between seemingly identical cells. Here we… Expand
Morphine activates neuroinflammation in a manner parallel to endotoxin
- X. Wang, L. Loram, +8 authors H. Yin
- Proceedings of the National Academy of Sciences
- 2 April 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be… Expand
Effect of Biochars from Rice Husk, Bran, and Straw on Heavy Metal Uptake by Pot-Grown Wheat Seedling in a Historically Contaminated Soil
The effect of biochar amendment of a multi-element contaminated soil on the transfer and accumulation of Cd, Zn, Pb, and As in wheat was investigated in this study. Addition of biochars from rice… Expand
Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury.
AIMS We have reported that either toll-like receptor 4 deficiency (TLR4(-/-)) or TLR2 modulation protects against myocardial ischaemia/reperfusion (I/R) injury. The mechanisms involve attenuation of… Expand
MicroRNA-125b protects against myocardial ischaemia/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6.
AIMS The present study examined the role of microRNA-125b (miR-125b) in myocardial ischaemia/reperfusion (I/R) injury. We constructed lentivirus-expressing miR-125b (LmiR-125b) and developed… Expand
HSPB2 Is Dispensable for the Cardiac Hypertrophic Response but Reduces Mitochondrial Energetics following Pressure Overload In Mice
Background CryAB (HspB5) and HspB2, two small heat shock genes located adjacently in the vertebrate genome, are hypothesized to play distinct roles. Mice lacking both cryab and hspb2 (DKO) are viable… Expand
Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction.
- S. Sena, P. Hu, +6 authors S. Litwin
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 1 June 2009
Diabetes increases mortality and accelerates left ventricular (LV) dysfunction following myocardial infarction (MI). This study sought to determine the impact of impaired myocardial insulin… Expand
CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: involving activation of PI3K/Akt signaling.
BACKGROUND Toll-like receptors (TLRs) have been implicated in myocardial ischemia/reperfusion (I/R) injury. The TLR9 ligand, CpG-ODN has been reported to improve cell survival. We examined effect of… Expand
MicroRNA-125b Prevents Cardiac Dysfunction in Polymicrobial Sepsis by Targeting TRAF6-Mediated Nuclear Factor κB Activation and p53-Mediated Apoptotic Signaling.
BACKGROUND This study examined the effect of microRNA-125b (miR-125b) on sepsis-induced cardiac dysfunction. METHODS Mouse hearts were transfected with lentivirus expressing miR-125b (LmiR-125b)… Expand