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Crystal structure of the catalytic domain of human plasmin complexed with streptokinase.
The crystal structure of streptokinase complexed with the catalytic unit of human plasmin was solved and the amino-terminal domain of strePTokinase in the complex is hypothesized to enhance the substrate recognition. Expand
Human plasminogen catalytic domain undergoes an unusual conformational change upon activation.
Activation of the serine protease plasmin from its zymogen, plasminogen, is the key step in fibrinolysis leading to blood clot dissolution. It also plays critical roles in cell migration, such as inExpand
The crystal structure of bovine bile salt activated lipase: insights into the bile salt activation mechanism.
Bile salts activate BAL by binding to a relatively short ten-residue loop near the active site, and stabilize the loop in an open conformation, which presumably leads to the formation of the substrate-binding site, as suggested from kinetic data. Expand
Activation of Toll-like receptor-3 induces interferon-λ expression in human neuronal cells
Direct and compelling evidence is provided that there is intracellular expression and regulation of IFN-lambda in human neuronal cells, which may have an important role in the innate neuronal protection against viral infections in the CNS. Expand
The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons
These cell lines will serve as novel tools for the analysis of the cellular and molecular mechanisms involved in hypothalamic control of a number of physiological processes described in the rat animal model. Expand
Acute actions of tumor necrosis factor-α on intracellular Ca2+ and K+ currents in human microglia
The signaling pathways involving TNFα modulation of [Ca 2+ ]i and K + channels in human microglia may contribute to functional and pathological actions of the cytokine in the brain. Expand
Laser cavity for generation of variable-radius rings of light.
A laser cavity that has a ring as its output mode that can be implemented in any tunable laser with large gain and can be useful when ring illumination patterns are needed. Expand
Product applications and technology directions with SiGe BiCMOS
  • J. Dunn, G. Freeman, +16 authors X. Wang
  • Computer Science
  • 24th Annual Technical Digest Gallium Arsenide…
  • 10 December 2002
The effectiveness and flexibility of SiGe BiCMOS as a technology platform over a wide range of performance and applications is highlighted. Expand
Thiamine deficiency induces endoplasmic reticulum stress in neurons
It is demonstrated here that TD up-regulated several markers of ER stress, such as glucose-regulated protein (GRP) 78, growth arrest and DNA-damage inducible protein or C/EBP-homologus protein (GADD153/Chop), phosphorylation of eIF2alpha and cleavage of caspase-12 in the cerebellum and the thalamus of mice. Expand
Substantial emission reductions from Chinese power plants after the introduction of ultra-low emissions standards
In 2014, China introduced an ultra-low emissions (ULE) standards policy for renovating coal-fired power-generating units to limit SO2, NOx and particulate matter (PM) emissions to 35, 50 and 10 mgExpand