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Polycyclic aromatic hydrocarbons in the surface soils from outskirts of Beijing, China.
Surface soils from the outskirts of Beijing were analyzed for 16 priority polycyclic aromatic hydrocarbons (PAHs) using gas chromatography and mass spectrometry (GC-MS). The distribution map of total… Expand
Harnessing a High Cargo-Capacity Transposon for Genetic Applications in Vertebrates
Viruses and transposons are efficient tools for permanently delivering foreign DNA into vertebrate genomes but exhibit diminished activity when cargo exceeds 8 kilobases (kb). This size restriction… Expand
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, but… Expand
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
- L. Bertram, C. Lange, +20 authors R. Tanzi
- Biology, Medicine
- American journal of human genetics
- 17 November 2008
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four genes have been established to either cause early-onset autosomal-dominant AD (APP, PSEN1, and PSEN2(1-4))… Expand
Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor.
- X. Wang, P. Roy, S. Holland, L. Zhang, J. Culotti, T. Pawson
- Medicine, Biology
- Molecular cell
- 1 December 1999
Eph receptor (EphR) tyrosine kinases and their ephrin ligands mediate direct cell-to-cell signaling. The C. elegans genome encodes four potential GPI-modified ephrins (EFN-1 to -4) and one EphR… Expand
GM130 Is Required for Compartmental Organization of Dendritic Golgi Outposts
Golgi complexes (Golgi) play important roles in the development and function of neurons [1-3]. Not only are Golgi present in the neuronal soma (somal Golgi), they also exist in the dendrites as Golgi… Expand
A RSC/Nucleosome Complex Determines Chromatin Architecture and Facilitates Activator Binding
How is chromatin architecture established and what role does it play in transcription? We show that the yeast regulatory locus UASg bears, in addition to binding sites for the activator Gal4, sites… Expand
Activator Control of Nucleosome Occupancy in Activation and Repression of Transcription
The relationship between chromatin structure and gene expression is a subject of intense study. The universal transcriptional activator Gal4 removes promoter nucleosomes as it triggers transcription,… Expand
Hyaluronic acid nanogels with enzyme-sensitive cross-linking group for drug delivery.
- Chenchen Yang, X. Wang, Xikuang Yao, Y. Zhang, Wei Wu, Xiqun Jiang
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 10 May 2015
A methacrylation strategy was employed to functionalize hyaluronic acid and prepare hyaluronic acid (HA) nanogels. Dynamic light scattering, zeta potential analyzer and electron microscopy were… Expand
An InDel in the Promoter of Al-ACTIVATED MALATE TRANSPORTER9 Selected during Tomato Domestication Determines Fruit Malate Contents and Aluminum Tolerance[OPEN]
Sl-ALMT9, directly regulated by Sl-WRKY42, contributes to fruit malate accumulation both in fruit and root and enhances aluminum tolerance of tomato. Deciphering the mechanism of malate accumulation… Expand