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Polycyclic aromatic hydrocarbons in the surface soils from outskirts of Beijing, China.
TLDR
The selected marked compounds, a principal component analysis (PCA) and special PAHs compound ratios suggest the pyrogenic origins, especially traffic exhausts, are the dominant sources ofPAHs in Beijing outskirts soils.
Harnessing a High Cargo-Capacity Transposon for Genetic Applications in Vertebrates
TLDR
It is shown that the Tol2 transposon can efficiently integrate DNA sequences larger than 10 kb into human cells and provides a novel nonviral vector for the delivery of large genetic payloads for gene therapy and other transgenic applications.
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
TLDR
This study provides compelling evidence for the existence of at least one previously undescribed AD gene that, like APOE-epsilon4, primarily acts as a modifier of onset age.
Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor.
Eph receptor (EphR) tyrosine kinases and their ephrin ligands mediate direct cell-to-cell signaling. The C. elegans genome encodes four potential GPI-modified ephrins (EFN-1 to -4) and one EphR
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
TLDR
It is concluded that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland.
A RSC/Nucleosome Complex Determines Chromatin Architecture and Facilitates Activator Binding
TLDR
The results show that both prior to and following induction, specific DNA-binding proteins are the predominant determinants of chromatin architecture at the GAL1/10 genes.
Activator Control of Nucleosome Occupancy in Activation and Repression of Transcription
TLDR
The results show how an activator's recruiting function can control chromatin structure both during gene activation and repression, and show that whereas promoter nucleosome removal invariably accompanies activation, reformation of nucleosomes is not required for repression.
Genetic Architecture of Highly Complex Chemical Resistance Traits across Four Yeast Strains
TLDR
Extreme QTL mapping is used to identify the genetic basis of resistance to 13 chemicals in all 6 pairwise crosses of four ecologically and genetically diverse yeast strains, and it is found that the number of loci detected in each experiment was primarily a function of the trait rather than the cross, suggesting that the level of genetic complexity is a consistent property of a trait across different genetic backgrounds.
GM130 Is Required for Compartmental Organization of Dendritic Golgi Outposts
TLDR
It is shown in Drosophila that, unlike somal Golgi, the biochemically distinct cis, medial, and trans compartments of Golgi are often disconnected in dendrites in vivo, which provides insights into the structure and function of dendritic Golgi outposts as well as the regulation of compartmental organization of GolGI in general.
Preparation and Characterization of Mesoporous Zirconia Made by Using a Poly (methyl methacrylate) Template
Superfine powders of poly (methyl methacrylate) (PMMA) have been prepared by means of an emulsion polymerization method. These have been used as templates in the synthesis of tetragonal phase
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