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Characterization of a reproducible rat model of hepatic veno‐occlusive disease
Lack of a reproducible animal model has hampered progress in understanding hepatic veno‐occlusive disease (HVOD). This article characterizes a reproducible model of HVOD. Rats gavaged withExpand
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Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence
Capillarization precedes hepatic fibrosis. We hypothesize that capillarization of sinusoidal endothelial cells (SEC) is permissive for hepatic stellate cell (HSC) activation and therefore permissiveExpand
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Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers.
BACKGROUND Current phenotyping of chronic rhinosinusitis (CRS) into chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) might not adequatelyExpand
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Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats.
BACKGROUND & AIMS Capillarization, characterized by loss of differentiation of liver sinusoidal endothelial cells (LSECs), precedes the onset of hepatic fibrosis. We investigated whether restorationExpand
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Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition.
BACKGROUND & AIMS The mechanical origins of the obstruction in sinusoidal obstruction syndrome are initiated by dehiscence of sinusoidal endothelial cells from the space of Disse. The biochemicalExpand
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Noninvasive bioluminescence imaging in small animals.
There has been a rapid growth of bioluminescence imaging applications in small animal models in recent years, propelled by the availability of instruments, analysis software, reagents, and creativeExpand
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The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth.
Posttranslational neddylation of cullins in the Cullin-Ring E3 ligase (CRL) complexes is needed for proteolytic degradation of CRL substrates, whose accumulation induces cell-cycle arrest, apoptosis,Expand
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The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a syndrome characterized by pulmonary edema and acute inflammation. Lipopolysaccharide (LPS), a major component in Gram-negativeExpand
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Preventing Stricture Formation by Covered Esophageal Stent Placement After Endoscopic Submucosal Dissection for Early Esophageal Cancer
ObjectiveWe aimed to evaluate the efficacy and safety of fully covered esophageal stent placement for preventing esophageal strictures after endoscopic submucosal dissection (ESD).MethodsTwenty-twoExpand
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