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A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients.
TLDR
It is shown in 2 independent cohorts with mixed etiologies and ethnicity that the metastasis gene signature is a useful tool to predict HCC outcome, suggesting the general utility of this classifier.
EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.
TLDR
The results suggest that HCC growth and invasiveness is dictated by a subset of EpCAM(+) cells, opening a new avenue for HCC cancer cell eradication by targeting Wnt/beta-catenin signaling components such as EpC AM.
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma.
TLDR
An easy classification system defined by EpCAM and AFP is proposed to reveal HCC subtypes similar to hepatic cell maturation lineages, which may enable prognostic stratification and assessment of H CC patients with adjuvant therapy and provide new insights into the potential cellular origin of HCC and its activated molecular pathways.
Identification of metastasis‐related microRNAs in hepatocellular carcinoma
TLDR
A unique 20‐miRNA metastasis signature is built that could significantly predict primary HCC tissues with venous metastases from metastasis‐free solitary tumors with 10‐fold cross‐validation and may provide a simple profiling method to assist in identifying patients with HCC who are likely to develop metastases/recurrence.
Predicting hepatitis B virus–positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
TLDR
Using a supervised machine-learning algorithm, a molecular signature is generated that can classify metastatic HCC patients and identified genes that were relevant to metastasis and patient survival and osteopontin was identified as a lead gene in the signature.
Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival.
TLDR
In vitro and in vivo analyses indicated that the products of PROSC, SH2D4A, and SORBS3 have tumor-suppressive activities, along with the known tumor suppressor gene DLC1.
Cancer stem cells in the development of liver cancer.
TLDR
An increased understanding of the molecular signaling events that regulate cellular hierarchy and stemness, and success in defining key CSC-specific genes, have opened up new avenues to accelerate the development of novel diagnostic and treatment strategies.
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45
TLDR
With the use of an antisense approach, reduced Gadd45 expression attenuated the suppression of Cdc2/Cyclin B1 activity in UV-irradiated human cells and implicate Gadd 45 in the control of G2/M cell cycle progression after certain stresses.
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