• Publications
  • Influence
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-methyladenosine (m6A) in mRNA processing and adipogenesis remains largely unknown. We show that FTO expression and m6AExpand
  • 416
  • 29
Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
The regulatory role of N(6)-methyladenosine (m(6)A) and its nuclear binding protein YTHDC1 in pre-mRNA splicing remains an enigma. Here we show that YTHDC1 promotes exon inclusion in targeted mRNAsExpand
  • 389
  • 23
  • PDF
5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader
5-methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is stillExpand
  • 200
  • 18
Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents
Honokiol and magnolol are the main constituents simultaneously identified in the barks of Magnolia officinalis, which have been used in traditional Chinese medicine to treat a variety of mentalExpand
  • 119
  • 4
Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice
BackgroundRenal organic ion transporters and uromodulin (UMOD) play the important roles in renal urate excretion and function. Hyperuricemia is considered as a risk factor for the development ofExpand
  • 37
  • 4
Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma.
Metadherin (MTDH), which is an HIV-1 or TNF-α-inducible transcript, has a crucial role in several types of cancer by regulating multiple cellular signaling processes. However, to date, the role ofExpand
  • 30
  • 3
  • PDF
Human herpesvirus 8: Serovprevalence and correlates in tumor patients from Xinjiang, China
Human herpesvirus 8 (HHV‐8), also known as Kaposi's sarcoma‐associated herpesvirus, is etiologically associated with Kaposi's sarcoma and other lymphoproliferative diseases. Although HHV‐8 prevalenceExpand
  • 31
  • 3
Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment‐naïve patients with chronic hepatitis B but not in patients with HBV related hepatocellular
The aim of the study was to investigate correlations between intrahepatic hepatitis B virus total DNA, covalently closed circular DNA (cccDNA), and serum HBsAg in treatment‐naïve chronic hepatitis BExpand
  • 26
  • 3
Role of microRNA-21 and effect on PTEN in Kazakh’s esophageal squamous cell carcinoma
The aim of this study was investigate the role of microRNA-21 (miR-21) and its regulation on phosphatase and tensin homolog deleted from chromosome-10 (PTEN) in Kazakh’s esophageal squamous cellExpand
  • 59
  • 2
Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin
Chemoresistance to cisplatin is a principal cause of treatment failure and mortality of advanced bladder cancer (BC). The underlying mechanisms remain unclear, which hinders the development ofExpand
  • 33
  • 2