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The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein
Autosomal recessive polycystic kidney disease (ARPKD) is characterized by dilation of collecting ducts and by biliary dysgenesis and is an important cause of renal- and liver-related morbidity and… Expand
Deep Supervised Hashing with Triplet Labels
Hashing is one of the most popular and powerful approximate nearest neighbor search techniques for large-scale image retrieval. Most traditional hashing methods first represent images as… Expand
Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist
The polycystic kidney diseases (PKDs) are a group of genetic disorders causing significant renal failure and death in children and adults. There are no effective treatments. Two childhood forms,… Expand
Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial.
- S. Chen, X. Zhao, +8 authors M. Mi
- Digestive and liver disease : official journal of…
- 1 March 2015
BACKGROUND Non-alcoholic fatty liver disease is a major health problem worldwide. Resveratrol is a natural polyphenol found in edible plants that has a variety of biochemical and physiological… Expand
A crucial role for hydrogen sulfide in oxygen sensing via modulating large conductance calcium-activated potassium channels.
Hydrogen sulfide (H(2)S) is an important signaling molecule produced from L-cysteine by cystathionine beta-synthetase (CBS) or cystathionine gamma-lyase (CSE). Here we examined the role of H(2)S in… Expand
Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.
Autosomal recessive polycystic kidney disease (ARPKD) is an infantile form of PKD characterized by fusiform dilation of collecting ducts and congenital hepatic fibrosis. The ARPKD gene, PKHD1, is… Expand
Specification of Region-Specific Neurons Including Forebrain Glutamatergic Neurons from Human Induced Pluripotent Stem Cells
Background Directed differentiation of human induced pluripotent stem cells (hiPSC) into functional, region-specific neural cells is a key step to realizing their therapeutic promise to treat various… Expand
Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice
Family with sequence similarity 20,-member C (FAM20C) is highly expressed in the mineralized tissues of mammals. Genetic studies showed that the loss-of-function mutations in FAM20C were associated… Expand
A Global/Local Affinity Graph for Image Segmentation
- X. Wang, Yuxing Tang, S. Masnou, Liming Chen
- Computer Science, Mathematics
- IEEE Transactions on Image Processing
- 27 January 2015
Construction of a reliable graph capturing perceptual grouping cues of an image is fundamental for graph-cut based image segmentation methods. In this paper, we propose a novel sparse global/local… Expand
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
- S. Charman, Sarah Arbe-Barnes, +24 authors J. Vennerstrom
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 7 February 2011
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase I clinical trials, where it was shown… Expand