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Cx43 reverses the resistance of A549 lung adenocarcinoma cells to cisplatin by inhibiting EMT.
TLDR
Cx43 reverses CDDP resistance in A549 CDDP-resistant cells by preventing EMT, making Cx43 a possible therapeutic target for lung cancer. Expand
Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway.
TLDR
Molecular data indicate that Dp3-Sam might induce apoptosis in HL-60 cells through a ROS-mediated mitochondrial dysfunction pathway, and findings enhance the understanding for anticancer function of Hibiscus anthocyanins in herbal medicine. Expand
Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules
The cytosolic reducing agent glutathione can reverse thiol modification of cysteine residues inside the pores of connexins and other channels permeable to large molecules.
Echinocystic acid induces apoptosis in HL-60 cells through mitochondria-mediated death pathway.
TLDR
It is reported that EA can induce apoptosis in human promyelocytic leukemia cells (HL-60), as characterized by DNA fragmentation, poly (ADP) ribose polymerase cleavage, and the efficacious induction of apoptosis was observed. Expand
Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis.
  • D. Hou, T. Uto, +5 authors M. Fujii
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 15 August 2004
TLDR
It is reported that gossypol could induce apoptosis in human promyelocytic leukemia cells (HL-60), as characterized by DNA fragmentation, poly(ADP) ribose polymerase (PARP) cleavage, and the efficacious induction of apoptosis was observed. Expand
Cisplatin and Oxaliplatin Inhibit Gap Junctional Communication by Direct Action and by Reduction of Connexin Expression, Thereby Counteracting Cytotoxic Efficacy
TLDR
Results indicate that inhibition of GJIC by cisplatin/oxaliplatin decreases their cytotoxicity, which may compromise the effectiveness of these compounds and be a factor in the development of resistance to this class of chemotherapeutic agents. Expand
JAK2/STAT3 pathway is involved in the protective effects of epidermal growth factor receptor activation against cerebral ischemia/reperfusion injury in rats
TLDR
It is implicate that JAK2/STAT3 pathway plays the vital role in I/R injury protection from activating EGFR, and the neuroprotective effects may associate with inhibiting the Cx43 expression and the inhibition of apoptosis. Expand
Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB.
TLDR
Observations indicate that berberine inhibits NF‑κB activation and may be used to enhance CPT‑11‑induced apoptosis in colon cancer. Expand
Connexin-dependent gap junction enhancement is involved in the synergistic effect of sorafenib and all-trans retinoic acid on HCC growth inhibition
TLDR
It is found that ATRA, at non-toxic concentrations, enhanced sorafenib-induced growth inhibition in both HCC cell lines, and this effect was abolished by two GJIC inhibitors, 18-α-GA and oleamide. Expand
Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin.
TLDR
GJIC protects normal cells from cisplatin toxicity while enhancing it in tumor cells, suggesting that enhancement/maintenance of GJIC increases therapeutic efficacy while decreasing off-target toxicity. Expand
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