• Publications
  • Influence
Unraveling and engineering the production of 23,24-bisnorcholenic steroids in sterol metabolism
The catabolism of sterols in mycobacteria is highly important due to its close relevance in the pathogenesis of pathogenic strains and the biotechnological applications of nonpathogenic strains forExpand
  • 27
  • 6
In vitro anti-tumor activity of isorhamnetin isolated from Hippophae rhamnoides L. against BEL-7402 cells.
Isorhamnetin, a flavonol aglycone, isolated from the traditional Chinese medicine Hippophae rhamnoides L., was investigated in its cytotoxicity and its influence on human hepatocellular carcinomaExpand
  • 111
  • 3
Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers.
Hb (hemoglobin)-loaded particles (HbP) encapsulated by a biodegradable polymer used as oxygen carrier were prepared. A modified double emulsion and solvent diffusion/evaporation method was adopted.Expand
  • 86
  • 2
Metabolic engineering of Pichia pastoris for the production of dammarenediol-II.
Dammarenediol-II is the nucleus of dammarane-type ginsenosides, which are a group of active triterpenoids exhibiting various pharmacological activities. Based on the native triterpene syntheticExpand
  • 22
  • 2
New compounds from a hydrothermal vent crab-associated fungus Aspergillus versicolor XZ-4.
Three new quinazoline derivatives (1-3), one new oxepin-containing natural product (4) and four new cyclopenin derivatives (5-7 and 9) have been isolated from an EtOAc extract of the TaiwanExpand
  • 14
  • 1
Engineering diverse eubacteria promoters for robust Gene expression in Streptomyces lividans.
Due to the lack of powerful gene regulation elements, the engineering development of Streptomyces is often limited. Here, we disclosed that the heterologous σ70 -dependent promoters, which have beenExpand
  • 3
  • 1
Tyrosinase inhibitory effect and inhibitory mechanism of tiliroside from raspberry
Tiliroside was found to inhibit both monophenolase and diphenolase activity of mushroom tyrosinase. The lag time of tyrosine oxidation catalyzed by mushroom tyrosinase was obviously lengthened; 0.337Expand
  • 21
The yeast peroxisome: A dynamic storage depot and subcellular factory for squalene overproduction.
Engineering microbes to produce terpenes from renewable feedstock is a promising alternative to traditional production approaches. Generally, terpenes are not readily secreted by microbial cells, andExpand
  • 16
RNA-Seq analysis uncovers non-coding small RNA system of Mycobacterium neoaurum in the metabolism of sterols to accumulate steroid intermediates
BackgroundUnderstanding the metabolic mechanism of sterols to produce valuable steroid intermediates in mycobacterium by a noncoding small RNA (sRNA) view is still limited. In the work, RNA-seq wasExpand
  • 7
Establishment of a low‐dosage‐IPTG inducible expression system construction method in Escherichia coli
The lac operon is a delicate inducible gene expression element in bacteria. To efficiently induce gene expression, a sufficient dosage of an inducer, usually that of 500–1000 µM isopropylExpand
  • 2