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Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells
TLDR
It is shown that human neutralizing antibodies could be efficiently discovered by high-throughput single B-cell sequencing in response to pandemic infectious diseases. Expand
The structural basis for the sensing and binding of cyclic di-GMP by STING
TLDR
The crystal structures of the STING cytoplasmic domain and its complex with c-di-GMP are reported, thus providing the structural basis for understanding STING function. Expand
Crystal structure of hemolin: a horseshoe shape with implications for homophilic adhesion.
Hemolin, an insect immunoglobulin superfamily member, is a lipopolysaccharide-binding immune protein induced during bacterial infection. The 3.1 angstrom crystal structure reveals a bound phosphateExpand
DNA binding mechanism revealed by high resolution crystal structure of Arabidopsis thaliana WRKY1 protein
TLDR
The crystal structure of the AtWRKY1-C determined at 1.6 Å resolution has revealed that this domain is composed of a globular structure with five β strands, forming an antiparallel β-sheet, which provided structural information to understand the mechanism of transcriptional control and signal transduction events of the WRKY proteins. Expand
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients
  • X. Ni, M. Zhuo, +22 authors Jie Wang
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 9 December 2013
TLDR
The use of the recently developed multiple annealing and looping-based amplification cycles for whole-genome amplification of single CTCs from lung cancer patients are reported, finding that copy number variations (CNVs), one of the major genomic variations, are specific to cancer types, reproducible from cell to cell, and even from patient to patient. Expand
RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas.
TLDR
This study profiles the shifting RNA landscape of gliomas during progression and reveled ZM as a novel, recurrent fusion transcript in sGBMs and revealed that the fusion arose from translocation events involving introns 3 or 8 of PTPRZ and intron 1 of MET. Expand
Fluorescent indicators for simultaneous reporting of all four cell cycle phases
TLDR
An intensiometric reporter of the transition from S to G2 phase is developed and a far-red fluorescent protein is engineered, mMaroon1, to visualize chromatin condensation in mitosis, to create Fucci4, a set of four orthogonal fluorescent indicators that together resolve all cell cycle phases. Expand
Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular weight protein tyrosine phosphatases
TLDR
The arsenate reduction in the light of low molecular weight protein tyrosine phosphatase mechanism is understood and the catalytic roles of essential residues such as Cys-10, Cys -82, Cymru-82, Arg-16, and Asp-105 are explained. Expand
CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy.
TLDR
Data suggest that CLIC2 can interact with skeletal ryanodine receptor (RyR1) and modulate its channel activity and propose that CL IC2 functions as an intrinsic stabilizer of the closed state of RyR channels. Expand
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
TLDR
Comparison of DctB, CitA, and DcuS suggests a detailed stereochemistry of C(4)-dicarboxylates ligand perception, and a series of conformational changes initiated upon ligand binding and propagated to the N-terminal domain responsible for dimerization provide insights into understanding the detailed mechanism of the signal transduction of TCS histidine kinases. Expand
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