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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

• Donalyn L. Scheuner, Christopher B. Eckman, +18 authors Samuel G. Younkin
• Nature medicine
• 1996

To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular… (More)

Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade.

• X. Song, Frederic J. Seidler, Jaber Saleh, J. Zhang, S. Padilla, T. A. Slotkin
• Toxicology and applied pharmacology
• 1997

Developmental neurotoxicity caused by chlorpyrifos exposure is generally thought to target cholinesterase but chlorpyrifos may also act on cellular intermediates, such as adenylyl cyclase, that serve… (More)

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

• Daniel J. Brat, Roel G. W. Verhaak, +304 authors Jianan Zhang
• The New England journal of medicine
• 2015

BACKGROUND Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that… (More)

Direct selection of human genomic loci by microarray hybridization

• Thomas Albert, Michael Molla, +9 authors Richard A. Gibbs
• Nature Methods
• 2007

We applied high-density microarrays to the enrichment of specific sequences from the human genome for high-throughput sequencing. After capture of 6,726 approximately 500-base 'exon' segments, and of… (More)

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing.

• Jianjun Zhang, Junya Fujimoto, +24 authors P. Andrew Futreal
• Science
• 2014

Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not been well studied. We… (More)

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

• Donalyn L. Scheuner, Christopher B. Eckman, +18 authors Samuel G. Younkin
• Nature Medicine
• 1996

To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid β-protein precursor (APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular concentration… (More)

Comprehensive molecular characterization of gastric adenocarcinoma

• Adam J. Bass, Vesteinn Thorsson, +257 authors Jia Liu
• Nature
• 2014

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a… (More)

The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2.

• A. L. Hsu, Tao Te Ching, D. S. Wang, X. Song, Vivek M. Rangnekar, C. S. Chen
• The Journal of biological chemistry
• 2000

This study investigates the apoptotic activity of the cyclooxygenase-2 (COX-2) inhibitor celecoxib in prostate carcinoma cells. COX-2 is constitutively expressed in androgen-responsive LNCaP and… (More)

Comprehensive genomic characterization of head and neck squamous cell carcinomas

• Reanne Bowlby, Denise Brooks, +63 authors Bartosz Szybiak
• Nature
• 2015

The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that… (More)

The genome of the sea urchin Strongylocentrotus purpuratus.

• Erica Sodergren, George M. Weinstock, +225 authors R. M. Wright
• Science
• 2006

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined… (More)

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