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Glucose promotes cell proliferation, glucose uptake and invasion in endometrial cancer cells via AMPK/mTOR/S6 and MAPK signaling.
OBJECTIVES Obesity and diabetes are well-known risk factors for the development of endometrial cancer. A high rate of aerobic glycolysis represents a key mechanism by which endometrial cancer cells… Expand
The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer
Ovarian cancer is the 5th leading cause of cancer death among women in the United States. The mevalonate pathway is thought to be a potential oncogenic pathway in the pathogenesis of ovarian cancer.… Expand
Clinical value of serum HMGB1 levels in early detection of recurrent squamous cell carcinoma of uterine cervix: comparison with serum SCCA, CYFRA21-1, and CEA levels.
AIM To evaluate the clinical value of serum high mobility group box chromosomal protein 1 (HMGB1) levels in making the early diagnosis of recurrent cervical squamous cell carcinomas (CSCC) and… Expand
Surgical morbidity and oncologic results after concurrent chemoradiation therapy for advanced cervical cancer
To evaluate the surgical morbidity and oncologic results after concurrent chemoradiotherapy (CCRT) followed by completion surgery for advanced cervical carcinoma.
Sparing of saphenous vein during inguinal lymphadenectomy for vulval malignancies.
OBJECTIVE This work was set out to investigate the effect of saphenous vein preservation during inguinal lymphadenectomy for patients with vulval malignancies. METHODS 64 patients with vulval… Expand
Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor-α-dependent gene expression.
- W. Zhang, Jo-Hsin Chen, +5 authors Yi-Wen Huang
- Biology, Medicine
- Molecular nutrition & food research
- 1 November 2016
SCOPE Obese and overweight women are at high risk of developing endometrial cancer; indeed, many of endometrial cancer patients are obese. The increased number and size of adipocytes due to obesity… Expand
The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention
Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer… Expand
Surgical and Oncologic Outcomes of Radical Abdominal Trachelectomy Versus Hysterectomy for Stage IA2-IB1 Cervical Cancer.
- J. Guo, Y. Zhang, X. Chen, Lin Sun, K. Chen, X. Sheng
- Journal of minimally invasive gynecology
STUDY OBJECTIVE To compare the surgical and oncologic outcomes between abdominal radical trachelectomy (ART) and radical hysterectomy (RH) for stage IA2-IB1 cervical cancer. DESIGN A retrospective… Expand
Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo
- Haiyan Zhang, Bei-Bei Xie, Z. Zhang, X. Sheng, Shiqian Zhang
- Chemistry, Medicine
- Drug design, development and therapy
- 20 December 2018
Introduction and aim Cervical cancers are the most common forms of cancer that occur in women globally and are difficult to be cured in their terminal stages. Tetrandrine (TET), a monomeric compound… Expand
Glutaminase inhibitor compound 968 inhibits cell proliferation and sensitizes paclitaxel in ovarian cancer.
- Lingqin Yuan, X. Sheng, +7 authors V. Bae-Jump
- Chemistry, Medicine
- American journal of translational research
OBJECTIVE Our overall goal was to investigate the anti-tumor activity of the glutaminase 1 (GLS1) Inhibitor compound 968 in ovarian cancer cells. The human ovarian cancer cell lines, HEY, SKOV3 and… Expand