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Characterization of EGFR family gene aberrations in cholangiocarcinoma.
Cholangiocarcinoma (CCA) is a highly lethal malignancy of the biliary tract with very few treatment options. Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER2)… Expand
Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer
Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer. Moreover, the impact of para-aortic lymph node (PAN) removal on patient prognosis is still unclear. In this… Expand
A 15-long non-coding RNA signature to improve prognosis prediction of cervical squamous cell carcinoma.
Long non-coding RNAs (lncRNAs), which have little or no protein-coding capacity, caught a particular interest since their potential roles in the cancer paradigm. As the most common cancer in women,… Expand
ERG Rearrangement Is Associated with Prostate Cancer-Related Death in Chinese Prostate Cancer Patients
Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and EGFR family aberrations were characterized as potential biomarkers for prostate cancer (PCa)… Expand
miR-22 is down-regulated in esophageal squamous cell carcinoma and inhibits cell migration and invasion
BackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most common and deadly forms of cancer. Despite advances in the diagnosis and treatment of this cancer, the survival rate at five… Expand
A Network Meta‐Analysis of Short and Long‐Term Efficacy of Targeted Therapy With Single or Double‐Drug Regimens in the Treatment of Stage III/IV Malignant Melanoma Based on 16 Randomized Controlled…
- Ting Xie, Chun-yu Huang, Xu Kang, Jiasheng Luo, X. Qin, F. Han
- Journal of cellular biochemistry
- 1 January 2018
For the treatment of stage III/IV malignant melanoma (MM), a network meta‐analysis (NMA) was conducted to compare the short and long‐term efficacy of targeted therapy with single or double‐drug… Expand
Epigenetic silencing of miR-137 induces drug resistance and chromosomal instability by targeting AURKA in multiple myeloma
Multiple myeloma (MM) is the second most prevalent hematologic malignancy. Aberrant microRNAs (miRNAs) expression has been shown to be involved in the pathogenesis of MM. In this study, we further… Expand
Harmful effect of ERβ on BCRP‐mediated drug resistance and cell proliferation in ERα/PR‐negative breast cancer
- Weiwei Li, Ming Jia, X. Qin, J. Hu, Xiaofang Zhang, Geng-yin Zhou
- The FEBS journal
- 1 December 2013
The role of estrogen receptor β (ERβ) in breast cancer is still under investigation. Various studies have provided evidence that ERβ behaves as a tumor suppressor in breast cancer, whereas some… Expand
Apoptosis of human non-small-cell lung cancer A549 cells triggered by evodiamine through MTDH-dependent signaling pathway
- Y. Zou, X. Qin, H. Xiong, Feng Zhu, T. Chen, Hong-ge Wu
- Biology, Medicine
- Tumor Biology
- 5 February 2015
Metadherin (MTDH), a novel oncoprotein, has been implicated in the carcinogenesis in various aspects of tumor malignancy. Overexpression of the MTDH promotes the survival and proliferation of lung… Expand
Inhibition of Akt signaling by SN-38 induces apoptosis in cervical cancer.
Cervical cancer still remains a major health problem in women worldwide. Inhibitors of topoisomerase I have proven to be among the most promising new classes of anti-neoplastic agents introducing… Expand