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Effects of Melatonin in Age‐Related Macular Degeneration
Age‐related macular degeneration (AMD) is the leading cause of severe visual loss in aged people. Melatonin has been shown to have the capacity to control eye pigmentation and thereby regulate theExpand
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Inhibitory effects of preimplantation exposure to bisphenol-A on blastocyst development and implantation.
The effect of preimplantation exposure to bisphenol-A (BPA) on blastocyst development and implantation is investigated. Mice were orally administered with BPA (200, 400, 600, and 800 mg/kg/day) fromExpand
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Development of 5-Fluorouracil derivatives as anticancer agents.
5-Fluorouracil (5-FU) is one of the most potent antimetabolites which have been widely used in the treatment of advanced solid tumors. As an anticancer agent, because of its low efficacy and highExpand
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Digestibility of gluten proteins is reduced by baking and enhanced by starch digestion
Scope Resistance of proteins to gastrointestinal digestion may play a role in determining immune‐mediated adverse reactions to foods. However, digestion studies have largely been restricted toExpand
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Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational Study
Objectives Our aim was to use the opportunity provided by the European Scleroderma Observational Study to (1) identify and describe those patients with early diffuse cutaneous systemic sclerosisExpand
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The effect of structural empowerment and organizational commitment on Chinese nurses' job satisfaction.
PURPOSES The purposes of this study were (1) to examine the level of structural empowerment, organizational commitment and job satisfaction in Chinese nurses; and (2) to investigate the relationshipsExpand
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SIRT6 protects against palmitate-induced pancreatic β-cell dysfunction and apoptosis.
Chronic exposure of pancreatic β-cells to abnormally elevated levels of free fatty acids can lead to β-cell dysfunction and even apoptosis, contributing to type 2 diabetes pathogenesis. In pancreaticExpand
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Discovery of novel anti-angiogenesis agents. Part 8: Diaryl thiourea bearing 1H-indazole-3-amine as multi-target RTKs inhibitors.
VEGFR-2, TIE-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, we designed and prepared three classes of multi-target inhibitors based on the extensive sequence homologyExpand
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Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus
Background The novel coronavirus disease (2019-nCoV) has been affecting global health since the end of 2019 and there is no sign that the epidemic is abating. The major issue for controlling theExpand
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PR‐957, a selective immunoproteasome inhibitor, reactivates latent HIV‐1 through p‐TEFb activation mediated by HSF‐1
  • Jian Lin, X. Zhang, +7 authors Shuwen Liu
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 29 August 2018
Graphical abstract Figure. No Caption available. Abstract The existence of latent reservoirs of Human Immunodeficiency Virus type‐1 (HIV‐1) is a major obstacle in eliminating the virus. Thus, anExpand
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