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Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies
A summarized review and analysis show that the pharmacological effects of and mechanisms underlying ginsenoside Rg1 activity against cerebral ischemia and reperfusion injury mainly involve 4 sets of mechanisms that result in significant neuroprotective effects against cortex ischemic injury. Expand
SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade
This study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy and shows a higher therapeutic efficacy than either monotherapy in controlling tumor growth in two colon cancer xenograft models, indicating that these agents complement each other. Expand
Myricitrin Protects against Doxorubicin-Induced Cardiotoxicity by Counteracting Oxidative Stress and Inhibiting Mitochondrial Apoptosis via ERK/P53 Pathway
Evaluated the possible protective effect of myricitrin against Dox-induced cardiotoxicity and the underlying mechanisms revealed that my Ricitrin-induced suppression of myocardial apoptosis relied on the ERK/p53-mediated mitochondrial apoptosis pathway. Expand
Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro
Findings indicated that isorhamnetin can be used as an adjuvant therapy for the long-term clinical use of Dox, and can counteract Dox-induced oxidative stress and suppress the activation of mitochondrion apoptotic pathway and mitogen-activated protein kinase pathway. Expand
Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway
Investigation of the possible protective effect of RK3 against hypoxia-reoxygenation (H/R) induced H9c2 cardiomyocytes damage and its underlying mechanisms revealed that RK2 has the potential to exert cardioprotective effects against H/R injury, which might be of great importance to clinical efficacy for AMI treatment. Expand
Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation.
Notoginsenoside R1 significantly counteracted the effects of Aβ by increasing cell viability, reducing oxidative damage (including apoptosis), restoring mitochondrial membrane potential, and suppressing stress-activated MAPK signaling pathways. Expand
Synthesis and structure-activity relationship of 4-azaheterocycle benzenesulfonamide derivatives as new microtubule-targeting agents.
A series of 1-sulfonyl indolines was synthesized and evaluated for antiproliferative activity, and the most potent compounds 9 a and 9 e showed significant cytotoxicity against four human cancer cell lines. Expand
Synthesis of Fucosylated Chondroitin Sulfate Glycoclusters: A Robust Route to New Anticoagulant Agents.
A facile method is reported for the synthesis of the repeating trisaccharide unit of FuCS based on the degradation of chondroitin sulfate polymers, which demonstrated potency to mimic linear glycosaminoglycans and offer a new framework for the development of novel anticoagulant agents. Expand
Elatoside C protects against ox-LDL-induced HUVECs injury by FoxO1-mediated autophagy induction.
The role of autophagy in the protective effects of EsC against ox-LDL-induced human umbilical vein endothelial cells (HUVECs) is determined and it is demonstrated that EsC pretreatment reduced ox- LDL- induced HUV ECs oxidative injury, increased the number of Autophagosomes and modulated the expression ofAutophagy related proteins. Expand
Concise synthesis and antitumor activity of Bengamide E and its analogs
Abstract Bengamide E (1a) and C-2 epimer (1b), free hydroxyl analogs (1c) and (1d), and shorter chain analog (1e) were synthesized by utilizing (2R,3S,4R)-2,3,4-tris(benzyloxy)hex-5-enal (2a) as theExpand