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Transforming growth factor-β1 reduces apoptosis via autophagy activation in hepatic stellate cells
TLDR
The possible functions of TGF-β1-mediated autophagy in the pathological process of liver fibrosis are elucidated and rescued HSC-T6 cells from serum deprivation and reduce apoptosis viaAutophagy induction is elucidated.
Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells
TLDR
Curcumin prevents carbon tetrachloride-induced liver fibrosis in rats and may be due to the inhibition of the activation of hepatic stellate cells and induction of their apoptosis.
Curcumin Promotes Apoptosis of Activated Hepatic Stellate Cells by Inhibiting Protein Expression of the MyD88 Pathway.
TLDR
It is demonstrated that curcumin promotes apoptosis of activated HSC by inhibiting the expression of cytokines related to the MyD88 pathway.
Curcumin, the main active constituent of turmeric (Curcuma longa L.), induces apoptosis in hepatic stellate cells by modulating the abundance of apoptosis-related growth factors
TLDR
Curcumin has an up-regulating effect on pro-apoptotic factors like Fas and p53 as well as a down- Regulating effect of the anti-ap optotic factor Bcl-2, thus inducing apoptosis in HSC.
MiR-1203 is involved in hepatocellular carcinoma metastases and indicates a poor prognosis.
TLDR
In conclusion, miR-1203 might promote HCC metastasis by decreasing SOCS3 and might serve as a potential therapeutic target for the prevention of HCC.
Percutaneous Endoscopic Gastrostomy/Jejunostomy Combined with Percutaneous Transhepatic Biliary Drainage in Treating Malignant Biliary Obstruction
TLDR
Combined PEG/PEJ and PTCD appeared to be safe and effective in the management of malignant biliary obstruction in patients with complete obstruction of the biliary tract.
711 HBM1022, a novel anti-CCR8 antibody depletes tumor-infiltrating regulatory T cells via enhanced ADCC activity, mediates potent anti-tumor activity with Keytruda
TLDR
The finding reveals HBM1022 as an innovative immunotherapy targeting intra-tumoral suppressive Treg cells to change suppressive tumor to hot tumor with enhanced antibody-dependent cell-mediated cytotoxicity (eADCC) activity, which suggests CCR8 as a promising therapeutic target.
β-Nerve growth factor attenuates hepatocyte injury induced by D-galactosamine in vitro via TrkA NGFR.
TLDR
The results suggested that exogenous β-NGF protects L-02 cells from D-GalN-induced injury through the NGF/TrkA NGFR signaling pathway.
[Preliminary study on mechanism of therapeutic effect of Huganjiexian decoction on hepatic fibrosis].
TLDR
Hananjiexian decoction can improve rat hepatic fibrosis, possibly via inhibiting the expression of collagen type I, collagen type III, TGFbeta1 and PDGF-BB.
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