• Publications
  • Influence
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
  • X. Lu, A. Barr, T. Bártfai
  • Biology, Psychology
    Proceedings of the National Academy of Sciences…
  • 18 January 2005
TLDR
It is demonstrated that 14 days of FLX treatment up-regulated galanin mRNA levels by 100% and GalR2-binding sites by 50%, in the rat dorsal raphe nucleus, where galAnin coexists with serotonin, underlining the connection between activation of the galan inergic system and antidepressant action of various clinically proven treatments.
Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests.
TLDR
The present work uses the tripeptidomimetic galnon and displays its presumed pharmacophores on a rigid molecular scaffold and provides an example of a systemically active compound based on a scaffold that mimics protein surfaces.
Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice
  • X. Lu, T. Bártfai
  • Biology
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 22 January 2009
TLDR
Current GalR1 and GalR2 antibodies, under standard immunodetection conditions, might not be suitable for mapping the receptors, and are argued for taking precaution when using antibodies to galanin receptors.
GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models
TLDR
CYM2503 provides a starting point for the development of anticonvulsant therapy using the galanin R2 receptor as target and attenuated electroshock-induced seizures in mice.
Receptor subtype‐dependent galanin actions on gamma‐aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala
TLDR
Galanin may act postsynaptically through GalR3 to augment GABAergic transmission in some CeA neurons, whereas GalR2 receptors likely are involved in the depression of IPSPs, suggesting the two agents act via different mechanisms in this population.
The brain galanin receptors: targets for novel antidepressant drugs.
TLDR
A body of existing data suggests that GalR2 signaling leads to antidepressant-like, anticonvulsant and neurogenesis-promoting effects, a spectrum of activities that are commonly associated with efficacious antidepressants.
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