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Comprehensive genomic profiles of small cell lung cancer
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimesExpand
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Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabaseExpand
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Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis. We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4 ±Expand
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A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control consortium
We present primary results from the Sequencing Quality Control (SEQC) project, coordinated by the US Food and Drug Administration. Examining Illumina HiSeq, Life Technologies SOLiD and Roche 454Expand
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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. We haveExpand
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The Ecology, Genetic Diversity, and Phylogeny of Huaiyangshan Virus in China
ABSTRACT Surveys were carried out to better understand the tick vector ecology and genetic diversity of Huaiyangshan virus (HYSV) in both regions of endemicity and regions of nonendemicity.Expand
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Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma
Background and aims Golgi protein 73 (GP73) as a potential serum marker for hepatocellular carcinoma (HCC) has not been validated in large cohort studies. Furthermore, its significance in theExpand
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Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?
Accumulation of p53 protein was seen in the nuclei of mammalian cells following DNA damage caused by ultraviolet radiation (UV), X-ray, or a restriction enzyme. Promoters containing p53-binding sitesExpand
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Total knee arthroplasty volume, utilization, and outcomes among Medicare beneficiaries, 1991-2010.
CONTEXT Total knee arthroplasty (TKA) is one of the most common and costly surgical procedures performed in the United States. OBJECTIVE To examine longitudinal trends in volume, utilization, andExpand
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Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia
Barrett's esophagus is an intestine-like metaplasia and precursor of esophageal adenocarcinoma. Triggered by gastroesophageal reflux disease, the origin of this metaplasia remains unknown.Expand
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