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A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
- Sung-Wuk Jang, X. Liu, +8 authors K. Ye
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 25 January 2010
Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis.… Expand
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.
The regulation and coordination of mitochondrial metabolism with hematopoietic stem cell (HSC) self-renewal and differentiation is not fully understood. Here we report that depletion of PTPMT1, a… Expand
Gossypium barbadense and Gossypium hirsutum genomes provide insights into the origin and evolution of allotetraploid cotton
Allotetraploid cotton is an economically important natural-fiber-producing crop worldwide. After polyploidization, Gossypium hirsutum L. evolved to produce a higher fiber yield and to better survive… Expand
The Iris Challenge Evaluation 2005
- P. Phillips, K. Bowyer, P. Flynn, X. Liu, W. T. Scruggs
- Computer Science
- IEEE Second International Conference on…
- 8 December 2008
This paper describes the Iris Challenge Evaluation (ICE) 2005. The ICE 2005 contains a dataset of 2953 iris images from 132 subjects. The data is organized into two experiments: right and left eye.… Expand
Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing.
OBJECTIVE To investigate the prevalence of eight common rheumatic diseases in a large Chinese population. METHODS A population-based epidemiological investigation of the prevalence of eight common… Expand
Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite.
The search for novel antimalarial drug targets is urgent due to the growing resistance of Plasmodium falciparum parasites to available drugs. Proteases are attractive antimalarial targets because of… Expand
Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex
Background:Metastasis associated with lung adenocarcinoma transcript-1 (MALAT1) is a functional long non-coding RNA (lncRNA), which is highly expressed in several tumours, including colorectal cancer… Expand
Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer
Tumor cells exhibit unique metabolic adaptations that are increasingly viewed as potential targets for novel and specific cancer therapies. Among these targets, the carnitine palmitoyltransferase… Expand
MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines
The vagus nerve can control inflammatory response through a 'cholinergic anti-inflammatory pathway', which is mediated by the α7-nicotinic acetylcholine receptor (α7nAChR) on macrophages. However,… Expand
A WRKY transcription factor participates in dehydration tolerance in Boea hygrometrica by binding to the W-box elements of the galactinol synthase (BhGolS1) promoter
Accumulation of compatible osmolytes, such as soluble sugars, in plants is an important osmoprotective mechanism. Sugars play a role in osmotic adjustment and are associated with stabilization of… Expand