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Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK
Significance Cancer cells reprogram their metabolism for optimal growth and survival. AMPK-activated protein kinase (AMPK) is a key energy sensor that controls many metabolic pathways includingExpand
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The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent
AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor important for cell growth, proliferation, survival, and metabolic regulation. Active AMPK inhibits biosyntheticExpand
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The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.
A prerequisite to myelination of peripheral axons by Schwann cells (SCs) is SC differentiation, and recent evidence indicates that reprogramming from a glycolytic to oxidative metabolism occursExpand
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Rubber plantation and its relationship with topographical factors in the border region of China, Laos and Myanmar
Rubber plantation is the major land use type in Southeast Asia. Monitoring the spatial-temporal pattern of rubber plantation is significant for regional land resource development, eco-environmentalExpand
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A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes
Despite the high response rates of individuals with myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)) to treatment with lenalidomide (LEN) and the recent identification ofExpand
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Sustained delivery of cytarabine-loaded vesicular phospholipid gels for treatment of xenografted glioma.
This study described the development of vesicular phospholipid gels (VPGs) for sustained delivery of cytarabine (Ara-C) for the treatment of xenografted glioma. Ara-C-loaded VPGs in the state of aExpand
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Direct Inhibition of Retinoblastoma Phosphorylation by Nimbolide Causes Cell-Cycle Arrest and Suppresses Glioblastoma Growth
Purpose: Classical pharmacology allows the use and development of conventional phytomedicine faster and more economically than conventional drugs. This approach should be tested for their efficacy inExpand
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Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Toll-like receptor (TLR) activation contributes to premalignant hematologic conditions, such as myelodysplastic syndromes (MDS). TRAF6, a TLR effector with ubiquitin (Ub) ligase activity, isExpand
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Behavioral and Psychosocial Interventions for HIV Prevention in Floating Populations in China over the Past Decade: A Systematic Literature Review and Meta-Analysis
Background Floating populations have been repeatedly characterized as “the tipping point” for the HIV epidemic in China. This study aims to systematically summarize and assess the effectiveness ofExpand
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Occupational exposure to blood and compliance with standard precautions among health care workers in Beijing, China
This cross-sectional survey assessed both risk and prevention of health care workers to bloodborne virus transmission in 2 hospitals in Beijing. The identifiedExpand
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