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The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription.
Antioncogene product p53 is a transcriptional transactivator. To investigate how p53 stimulates transcription, we examined the interaction of p53 with general transcription factors in vitro. We foundExpand
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Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain‐derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5
  • X. Liu, R. Jaenisch
  • Medicine, Biology
  • Developmental dynamics : an official publication…
  • 1 May 2000
Neurotrophins are a family of structurally and functionally related proteins that regulate neuronal survival during development. In the peripheral nervous system (PNS), both in vitro and in vivoExpand
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Hemogenic endocardium contributes to transient definitive hematopoiesis
Hematopoietic cells arise from spatiotemporally restricted domains in the developing embryo. Although studies of non-mammalian animal and in vitro embryonic stem cell models suggest a closeExpand
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First Results from CUORE: A Search for Lepton Number Violation via 0νββ Decay of ^{130}Te.
The CUORE experiment, a ton-scale cryogenic bolometer array, recently began operation at the Laboratori Nazionali del Gran Sasso in Italy. The array represents a significant advancement in thisExpand
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Reversal of in vitro p53 squelching by both TFIIB and TFIID.
  • X. Liu, A. Berk
  • Biology, Medicine
  • Molecular and cellular biology
  • 1 November 1995
p53, the protein encoded by one of the most significant human tumor suppressor genes, is a sequence-specific transcriptional activator. When activated by a double-stranded DNA break, p53 functionExpand
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No Association between EGF +61 A/G Polymorphism and Increased Risk of Glioma
A single nucleotide polymorphism (SNP) of the epidermal growth factor (EGF) gene +61 A/G in the 5’-untranslated region has been reported to be associated with susceptibility to glioma. A case-controlExpand
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ZnO nanorods/Au hybrid nanocomposites for glucose biosensor.
ZnO nanorods/Au hybrid nanocomposites (ZnO/Au) with Au nanocrystals growing on the surface of ZnO nanorods were synthesized via a simple and facile hydrothermal route. The prepared ZnO/AuExpand
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Identification of genes controlling malpighian tubule and other epithelial morphogenesis in Drosophila melanogaster.
The Drosophila Malpighian tubule is a model system for studying genetic mechanisms that control epithelial morphogenesis. From a screen of 1800 second chromosome lethal lines, by observing uric acidExpand
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Metadherin Contributes to the Pathogenesis of Diffuse Large B-cell Lymphoma
Background Metadherin (MTDH) has been demonstrated as a potentially crucial mediator of various types of human malignancies. However, the expression and role of MTDH in diffuse large-B-cell lymphomaExpand
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Designing Microblog Direct Messages to Engage Social Media Users With Suicide Ideation: Interview and Survey Study on Weibo
Background While Web-based interventions can be efficacious, engaging a target population’s attention remains challenging. We argue that strategies to draw such a population’s attention should beExpand
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