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CD47 Blockade Triggers T cell-mediated Destruction of Immunogenic Tumors
Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies has been proposed to be the major effector mechanism in xenograft models. Here, using syngeneic immunocompetent… Expand
QDMR: a quantitative method for identification of differentially methylated regions by entropy
DNA methylation plays critical roles in transcriptional regulation and chromatin remodeling. Differentially methylated regions (DMRs) have important implications for development, aging and diseases.… Expand
Cadmium (Cd) distribution and contamination in Chinese paddy soils on national scale
- X. Liu, G. Tian, D. Jiang, C. Zhang, L. Kong
- Medicine, Chemistry
- Environmental Science and Pollution Research
- 2 June 2016
Rice is a staple food by an increasing number of people in China. As more issues have arisen in China due to rice contaminated by cadmium (Cd), Cd contamination in arable soils has become a severe… Expand
Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease
Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that sodium phenylbutyrate (NaPB), an FDA-approved therapy for reducing… Expand
Childhood Sexual Abuse and the Development of Recurrent Major Depression in Chinese Women
Background Our prior study in Han Chinese women has shown that women with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship… Expand
Covariation in Plant Functional Traits and Soil Fertility within Two Species-Rich Forests
The distribution of plant species along environmental gradients is expected to be predictable based on organismal function. Plant functional trait research has shown that trait values generally vary… Expand
Cyclic AMP Response Element Modulator-1 (CREM-1) Involves in Neuronal Apoptosis after Traumatic Brain Injury
The cyclic AMP response element-binding protein (CREB) family can regulate biological functions of various types of cells by forming homo- or heterodimers to bind the target DNA sequences; it plays… Expand
Croll revisited: Why is the northern hemisphere warmer than the southern hemisphere?
AbstractThe question of why, in the annual-mean, the northern hemisphere (NH) is warmer than the southern hemisphere (SH) is addressed, revisiting an 1870 paper by James Croll. We first show that… Expand
Label-Free and Enzyme-Free Homogeneous Electrochemical Biosensing Strategy Based on Hybridization Chain Reaction: A Facile, Sensitive, and Highly Specific MicroRNA Assay.
Homogenous electrochemical biosensing strategies have attracted substantial attention, because of their advantages of being immobilization-free and having rapid response and improved recognition… Expand
CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells