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- Publications
- Influence
MiR-15a and miR-16-1 cluster functions in human leukemia
- G. Calin, A. Cimmino, +15 authors C. Croce
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 1 April 2008
MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression that play roles in human diseases, including cancer. Each miRNA is predicted to regulate hundreds of transcripts, but only few… Expand
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
MicroRNAs (miRNAs) are generated by two-step processing to yield small RNAs that negatively regulate target gene expression at the post-transcriptional level. Deregulation of miRNAs has been linked… Expand
Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.
Noncoding RNA (ncRNA) transcripts are thought to be involved in human tumorigenesis. We report that a large fraction of genomic ultraconserved regions (UCRs) encode a particular set of ncRNAs whose… Expand
Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.
- X. Liu, Y. Sun, S. Constantinescu, E. Karam, R. Weinberg, H. Lodish
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 30 September 1997
Drosophila Mad proteins are intracellular signal transducers of decapentaplegic (dpp), the Drosophila transforming growth factor beta (TGF-beta)/bone morphogenic protein (BMP) homolog. Studies in… Expand
Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells.
MicroRNAs are short non-coding RNA molecules able to affect stability and/or translation of mRNA, thereby regulating the expression of genes involved in many biological processes. We report here that… Expand
Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development.
- X. Liu, H. Wu, M. Byrne, S. Krane, R. Jaenisch
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 4 March 1997
Type III collagen is a fibrillar forming collagen comprising three alpha1(III) chains and is expressed in early embryos and throughout embryogenesis. In the adult, type III collagen is a major… Expand
Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells
beclin 1, the mammalian homologue of the yeast Atg6, is a key autophagy-promoting gene that plays a critical role in the regulation of cell death and survival of various types of cells. However,… Expand
A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling
- X. Liu, H. Wu, M. Byrne, J. Jeffrey, S. Krane, R. Jaenisch
- Biology, Medicine
- The Journal of cell biology
- 1 July 1995
Degradation of type I collagen, the most abundant collagen, is initiated by collagenase cleavage at a highly conserved site between Gly775 and Ile776 of the alpha 1 (I) chain. Mutations at or around… Expand
Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission
- X. Liu, H. Wu, +4 authors R. Jaenisch
- Biology, Medicine
- Developmental dynamics : an official publication…
- 1 May 1997
The ability to contribute to the germ line is the most important experimental feature of embryonic stem (ES) cells. Using ES cells, it is possible to introduce targeted mutations into any gene and to… Expand
Epigenetic regulation of miR-34a expression in alcoholic liver injury.
- F. Meng, S. Glaser, +14 authors G. Alpini
- Biology, Medicine
- The American journal of pathology
- 1 September 2012
Epigenetic changes are associated with the regulation of transcription of key cell regulatory genes [micro RNAs (miRNAs)] during different types of liver injury. This study evaluated the role of… Expand