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MiR-15a and miR-16-1 cluster functions in human leukemia
MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression that play roles in human diseases, including cancer. Each miRNA is predicted to regulate hundreds of transcripts, but only fewExpand
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EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
MicroRNAs (miRNAs) are generated by two-step processing to yield small RNAs that negatively regulate target gene expression at the post-transcriptional level. Deregulation of miRNAs has been linkedExpand
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Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.
Noncoding RNA (ncRNA) transcripts are thought to be involved in human tumorigenesis. We report that a large fraction of genomic ultraconserved regions (UCRs) encode a particular set of ncRNAs whoseExpand
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Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.
Drosophila Mad proteins are intracellular signal transducers of decapentaplegic (dpp), the Drosophila transforming growth factor beta (TGF-beta)/bone morphogenic protein (BMP) homolog. Studies inExpand
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Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells.
  • H. Zhu, H. Wu, +4 authors J. Yang
  • Biology, Medicine
  • Biochemical pharmacology
  • 1 September 2008
MicroRNAs are short non-coding RNA molecules able to affect stability and/or translation of mRNA, thereby regulating the expression of genes involved in many biological processes. We report here thatExpand
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Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development.
Type III collagen is a fibrillar forming collagen comprising three alpha1(III) chains and is expressed in early embryos and throughout embryogenesis. In the adult, type III collagen is a majorExpand
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Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells
beclin 1, the mammalian homologue of the yeast Atg6, is a key autophagy-promoting gene that plays a critical role in the regulation of cell death and survival of various types of cells. However,Expand
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A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling
Degradation of type I collagen, the most abundant collagen, is initiated by collagenase cleavage at a highly conserved site between Gly775 and Ile776 of the alpha 1 (I) chain. Mutations at or aroundExpand
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Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission
  • X. Liu, H. Wu, +4 authors R. Jaenisch
  • Biology, Medicine
  • Developmental dynamics : an official publication…
  • 1 May 1997
The ability to contribute to the germ line is the most important experimental feature of embryonic stem (ES) cells. Using ES cells, it is possible to introduce targeted mutations into any gene and toExpand
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Epigenetic regulation of miR-34a expression in alcoholic liver injury.
Epigenetic changes are associated with the regulation of transcription of key cell regulatory genes [micro RNAs (miRNAs)] during different types of liver injury. This study evaluated the role ofExpand
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