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PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling
TGFbeta signaling controls diverse normal developmental processes and pathogenesis of diseases including cancer and autoimmune and fibrotic diseases. TGFbeta responses are generally mediated throughExpand
Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.
The transcription corepressor CtBP is often recruited to the target promoter via interaction with a conserved PxDLS motif in the interacting repressor. In this study, we demonstrate that CtBP1 wasExpand
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐β
Transforming growth factor‐β (TGF‐β) arrests growth of epithelial cells by inducing the transcription of p15Ink4B, a cyclin‐dependent kinase inhibitor. In this study, we demonstrate that p15Ink4BExpand
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.
IKKbeta serves as a central intermediate signaling molecule in the activation of the NF-kappaB pathway. However, the precise mechanism for the termination of IKKbeta activity is still not fullyExpand
TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members.
Vimentin exhibits a complex pattern of developmental and tissue-specific expression regulated by such growth factors as TGFbeta1, PDGF, FGF, EGF and cytokines. Vimentin is expressed in the moreExpand
Critical regulation of TGFβ signaling by Hsp90
Transforming growth factor β (TGFβ) controls a diverse set of cellular processes by activating TGFβ type I (TβRI) and type II (TβRII) serine-threonine receptor kinases. Canonical TGFβ signaling isExpand
SUMO-1/Ubc9 Promotes Nuclear Accumulation and Metabolic Stability of Tumor Suppressor Smad4*
Tumor suppressor Smad4/DPC4 is a central intracellular signal transducer for transforming growth factor-β (TGF-β) signaling. We recently reported that transcriptional potential of Smad4 was regulatedExpand
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis
Mutations in phosphatase and tensin homologue (PTEN) or genomic alterations in the phosphatidylinositol-3-OH kinase-signalling pathway are the most common genetic alterations reported in humanExpand
Smad3 Differentially Regulates the Induction of Regulatory and Inflammatory T Cell Differentiation*
Transforming growth factor β (TGF-β) is a crucial cytokine with pleiotropic functions on immune cells. In CD4+ T cells, TGF-β is required for induction of both regulatory T and Th17 cells. However,Expand
Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling*
TGF-β is a pleiotropic cytokine that regulates a wide range of cellular actions and pathophysiological processes. TGF-β signaling is spatiotemporally fine-tuned. As a key negative regulator of TGF-βExpand