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Specification of motoneurons from human embryonic stem cells
An understanding of how mammalian stem cells produce specific neuronal subtypes remains elusive. Here we show that human embryonic stem cells generated early neuroectodermal cells, which organized… Expand
Pax6 is a human neuroectoderm cell fate determinant.
The transcriptional regulation of neuroectoderm (NE) specification is unknown. Here we show that Pax6 is uniformly expressed in early NE cells of human fetuses and those differentiated from human… Expand
The effects of curcumin on depressive-like behaviors in mice.
- Ying Xu, Bao-shan Ku, +4 authors X. Li
- Medicine, Chemistry
- European journal of pharmacology
- 25 July 2005
Curcuma longa is a major constituent of Xiaoyao-san, the traditional Chinese medicinal formula, which has been used effectively to treat depression-related diseases in China. There is no information… Expand
The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors.
Curcuma longa is a main constituent of many traditional Chinese medicines, such as Xiaoyao-san, used to manage mental disorders effectively. Curcumin is a major active component of C. longa and its… Expand
Curcumin produces neuroprotective effects via activating brain-derived neurotrophic factor/TrkB-dependent MAPK and PI-3K cascades in rodent cortical neurons
- R. Wang, Yuhua Li, Y. Xu, Y. Li, X. Li
- Biology, Medicine
- Progress in Neuro-Psychopharmacology and…
- 1 February 2010
Curcumin is a major constituent of curcuma longa, a traditional medicine used to manage mental disorders effectively in China. The neuroprotective effects of curcumin have been demonstrated in our… Expand
Expression and canalicular localization of two isoforms of the ClC-3 chloride channel from rat hepatocytes.
- K. Shimada, X. Li, G. Xu, D. E. Nowak, L. A. Showalter, S. Weinman
- Medicine, Biology
- American journal of physiology. Gastrointestinal…
- 1 August 2000
The molecular identities of functional chloride channels in hepatocytes are largely unknown. We examined the ClC-3 chloride channel in rat hepatocytes and found that mRNA for two different isoforms… Expand
Ginsenoside Rg3 attenuates cell migration via inhibition of aquaporin 1 expression in PC-3M prostate cancer cells.
Ginsenoside Rg3 (Rg3), one of the bioactive extracts found in ginseng root, was reported to have anti-cancer activity in various cancer models. The anti-proliferation effect of Rg3 on prostate cancer… Expand
Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage
Our study first proposed that curcumin could protect human endothelial cells from the damage caused by oxidative stress via autophagy. Furthermore, our results revealed that curcumin causes some… Expand
Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB
Curcumin is a major active component isolated from Curcuma longa. Previously, we have reported its significant antidepressant effect. However, the mechanisms underlying the antidepressant effects are… Expand
Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke
Mounting evidence suggests that epigenetic modifications play critical roles in the survival/death of stressed neurons. Chief among these modifications is the deacetylation of histones within the… Expand