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P53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivation.
Colorectal cancer (CRC) is one of the most common malignancies with high prevalence and low 5-year survival. CRC is a heterogeneous disease with a complex, genetic and biochemical background. It is… Expand
PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms
PRIMA-1met (APR-246) is a methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis). PRIMA-1met has been reported to restore both the wild type… Expand
Tumor-derived exosomes in colorectal cancer progression and their clinical applications
Colorectal cancer (CRC) ranks as the third leading cause of cancer mortality in both of men and women worldwide due to its metastatic properties and resistance to current treatment. Recent studies… Expand
[The effect of neuromuscular blocking agents on prognosis of patients with acute respiratory distress syndrome: a meta analysis].
- A. Wang, J. Gao, X. Li, Y. Leng, Zhi-yuan Yao, X. Zhu
- Zhonghua wei zhong bing ji jiu yi xue
- 1 March 2013
OBJECTIVE To determine the effects of neuromuscular blocking agent (NMBA) on prognosis of patients with acute respiratory distress syndrome (ARDS). METHODS PubMed database, the Cochrane Library,… Expand
[The effects of β-elemene on rabbit VX2 laryngeal carcinoma and factors associated with tumor growth and metastasis].
- W. Zhao, Z. Zhao, Q. Wang, X. Li, C. Xie, Z. Cao
- Zhonghua er bi yan hou tou jing wai ke za zhi…
- 7 August 2016
OBJECTIVE To investigate the inhibition effect of β-elemene on the growth and metastasis of laryngeal carcinoma and the underlying mechanism. METHODS Sixty-six rabbits were vaccinated with… Expand
Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy
The aim of the study was to compare the clinical effects of carvedilol and trimetazidine for the treatment of alcoholic cardiomyopathy. A total of 60 patients diagnosed with alcoholic cardiomyopathy… Expand
Characterization and functional analysis of a slow-cycling subpopulation in colorectal cancer enriched by cell cycle inducer combined chemotherapy
The concept of cancer stem cells has been proposed in various malignancies including colorectal cancer. Recent studies show direct evidence for quiescence slow-cycling cells playing a role in cancer… Expand
[Role of prone position mechanical ventilation in patients with acute respiratory distress syndrome originating from pulmonary disease and extra-pulmonary disease].
OBJECTIVE To assess the effect of mechanical ventilation on prone position for the treatment of acute respiratory distress syndrome (ARDS) originating from pulmonary disease and extra-pulmonary… Expand