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- Publications
- Influence
Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion.
- J. Haller, F. Bandello, +9 authors S. Whitcup
- Medicine
- Ophthalmology
- 1 June 2010
OBJECTIVE
To evaluate the safety and efficacy of dexamethasone intravitreal implant (DEX implant; OZURDEX, Allergan, Inc., Irvine, CA) compared with sham in eyes with vision loss due to macular edema… Expand
Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema.
- D. Boyer, Y. Yoon, +7 authors S. Whitcup
- Medicine
- Ophthalmology
- 1 October 2014
PURPOSE
To evaluate the safety and efficacy of dexamethasone intravitreal implant (Ozurdex, DEX implant) 0.7 and 0.35 mg in the treatment of patients with diabetic macular edema (DME).
DESIGN
Two… Expand
A cancer cell metalloprotease triad regulates the basement membrane transmigration program.
- K. Hotary, X. Li, Edward Allen, S. Stevens, S. Weiss
- Biology, Medicine
- Genes & development
- 1 October 2006
Carcinoma cells initiate the metastatic cascade by inserting invasive pseudopodia through breaches in the basement membrane (BM), a specialized barrier of cross-linked, extracellular matrix… Expand
Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results.
- J. Haller, F. Bandello, +9 authors J. Li
- Medicine
- Ophthalmology
- 1 December 2011
OBJECTIVE
To evaluate the safety and efficacy of 1 or 2 treatments with dexamethasone intravitreal implant (DEX implant) over 12 months in eyes with macular edema owing to branch or central retinal… Expand
Wnt-dependent Regulation of the E-cadherin Repressor Snail*
- J. I. Yook, X. Li, I. Ota, E. Fearon, S. Weiss
- Biology, Medicine
- Journal of Biological Chemistry
- 25 March 2005
Down-regulation of E-cadherin marks the initiation of the epithelial-mesenchymal transition, a process exploited by invasive cancer cells. The zinc finger transcription factor, Snail, functions as a… Expand
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition
- N. Kim, H. Kim, +12 authors J. I. Yook
- Biology, Medicine
- The Journal of cell biology
- 31 October 2011
Expression of the essential EMT inducer Snail1 is inhibited by miR-34 through a p53-dependent regulatory pathway.
A Wnt–Axin2–GSK3β cascade regulates Snail1 activity in breast cancer cells
- J. I. Yook, X. Li, +9 authors S. Weiss
- Biology
- Nature Cell Biology
- 1 December 2006
Accumulating evidence indicates that hyperactive Wnt signalling occurs in association with the development and progression of human breast cancer. As a consequence of engaging the canonical Wnt… Expand
Matrix Metalloproteinases (MMPs) Regulate Fibrin-invasive Activity via MT1-MMP–dependent and –independent Processes
- K. Hotary, I. Yana, +6 authors S. Weiss
- Chemistry, Medicine
- The Journal of experimental medicine
- 4 February 2002
Cross-linked fibrin is deposited in tissues surrounding wounds, inflammatory sites, or tumors and serves not only as a supporting substratum for trafficking cells, but also as a structural barrier to… Expand
Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase.
- X. Li, I. Ota, I. Yana, F. Sabeh, S. Weiss
- Biology, Medicine
- Molecular biology of the cell
- 1 August 2008
Membrane type-1 matrix metalloproteinase (MT1-MMP) drives cell invasion through three-dimensional (3-D) extracellular matrix (ECM) barriers dominated by type I collagen or fibrin. Based largely on… Expand
p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling
The tumor suppressor p53 activates miRNA-34 to inhibit Wnt signaling and colorectal cancer cell invasiveness. p53 Activates MicroRNA-34 to Inhibit Wnt Signaling The tumor suppressor p53 is missing or… Expand